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Review

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

1
Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA
2
School of Nursing, College of Nursing and Health Sciences, The University of Texas at Tyler, Tyler, TX 75799, USA
3
Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
*
Author to whom correspondence should be addressed.
Bioengineering 2018, 5(1), 9; https://doi.org/10.3390/bioengineering5010009
Received: 19 December 2017 / Revised: 17 January 2018 / Accepted: 22 January 2018 / Published: 27 January 2018
(This article belongs to the Special Issue Advances in Wound Healing Systems)
Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds. View Full-Text
Keywords: electrospun fibers; drug release; small molecule drugs; proteins and peptides; gene vectors; composites electrospun fibers; drug release; small molecule drugs; proteins and peptides; gene vectors; composites
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MDPI and ACS Style

Gizaw, M.; Thompson, J.; Faglie, A.; Lee, S.-Y.; Neuenschwander, P.; Chou, S.-F. Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications. Bioengineering 2018, 5, 9. https://doi.org/10.3390/bioengineering5010009

AMA Style

Gizaw M, Thompson J, Faglie A, Lee S-Y, Neuenschwander P, Chou S-F. Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications. Bioengineering. 2018; 5(1):9. https://doi.org/10.3390/bioengineering5010009

Chicago/Turabian Style

Gizaw, Mulugeta, Jeffrey Thompson, Addison Faglie, Shih-Yu Lee, Pierre Neuenschwander, and Shih-Feng Chou. 2018. "Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications" Bioengineering 5, no. 1: 9. https://doi.org/10.3390/bioengineering5010009

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