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Article

Topical Digitoxigenin for Wound Healing: A Feasibility Study

1
Department of Pharmaceutical Science and Research, School of Pharmacy, Marshall University, One John Marshall Drive, Huntington, WV 25755, USA
2
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
3
Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, WV 25703, USA
*
Author to whom correspondence should be addressed.
Bioengineering 2018, 5(1), 21; https://doi.org/10.3390/bioengineering5010021
Received: 5 February 2018 / Revised: 24 February 2018 / Accepted: 2 March 2018 / Published: 5 March 2018
(This article belongs to the Special Issue Advances in Wound Healing Systems)
(1) Background: Cardiotonic steroids have been found to stimulate collagen synthesis and might be potential wound healing therapeutics. The objective of this study was to evaluate the feasibility of digitoxigenin and its topical formulation for wound healing; (2) Methods: In the in vitro study, the human dermal fibroblast cells were treated with digitoxigenin and collagen synthesis was assessed. In the in vivo study, digitoxigenin was applied to excisional full-thickness wounds in rats immediately after wounding and remained for three days, and wound open was evaluated over 10 days. A digitoxigenin formulation for topical administration was prepared, and the in vitro release and in vivo wound healing effect were investigated; (3) Results: The expression of procollagen in human dermal fibroblast was significantly increased with the exposure to 0.1 nM digitoxigenin. Topical application of digitoxigenin in olive oil or alginate solution for three days significantly decreased the wound open in rats. Similarly, topical administration of the developed digitoxigenin formulation for three days also significantly increased wound healing. No wound healing effects were observed at days 7 and 10 after wounding when digitoxigenin was not applied; and, (4) Conclusions: It was possible to deliver digitoxigenin using the developed formulation. However, the wound healing effect of digitoxigenin and its mechanisms need to be further investigated in future studies. View Full-Text
Keywords: digitoxigenin; wound healing; full-thickness excision wound; human dermal fibroblast; alginate digitoxigenin; wound healing; full-thickness excision wound; human dermal fibroblast; alginate
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MDPI and ACS Style

Feng, X.; Wang, C.; Xu, Y.; Turley, J.; Xie, Z.; Pierre, S.V.; Hao, J. Topical Digitoxigenin for Wound Healing: A Feasibility Study. Bioengineering 2018, 5, 21. https://doi.org/10.3390/bioengineering5010021

AMA Style

Feng X, Wang C, Xu Y, Turley J, Xie Z, Pierre SV, Hao J. Topical Digitoxigenin for Wound Healing: A Feasibility Study. Bioengineering. 2018; 5(1):21. https://doi.org/10.3390/bioengineering5010021

Chicago/Turabian Style

Feng, Xinchi; Wang, Cuifen; Xu, Yunhui; Turley, Joel; Xie, Zijian; Pierre, Sandrine V.; Hao, Jinsong. 2018. "Topical Digitoxigenin for Wound Healing: A Feasibility Study" Bioengineering 5, no. 1: 21. https://doi.org/10.3390/bioengineering5010021

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