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Open AccessReview

Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials

by Donald C. Aduba, Jr. 1 and Hu Yang 2,3,4,*
1
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
2
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
3
Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA
4
Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ramana Pidaparti
Bioengineering 2017, 4(1), 1; https://doi.org/10.3390/bioengineering4010001
Received: 31 October 2016 / Revised: 5 January 2017 / Accepted: 7 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue Advanced Drug Delivery Systems and Devices)
Wound dressings are critical for wound care because they provide a physical barrier between the injury site and outside environment, preventing further damage or infection. Wound dressings also manage and even encourage the wound healing process for proper recovery. Polysaccharide biopolymers are slowly becoming popular as modern wound dressings materials because they are naturally derived, highly abundant, inexpensive, absorbent, non-toxic and non-immunogenic. Polysaccharide biopolymers have also been processed into biomimetic platforms that offer a bioactive component in wound dressings that aid the healing process. This review primarily focuses on the fabrication and biocompatibility assessment of polysaccharide materials. Specifically, fabrication platforms such as electrospun fibers and hydrogels, their fabrication considerations and popular polysaccharides such as chitosan, alginate, and hyaluronic acid among emerging options such as arabinoxylan are discussed. A survey of biocompatibility and bioactive molecule release studies, leveraging polysaccharide’s naturally derived properties, is highlighted in the text, while challenges and future directions for wound dressing development using emerging fabrication techniques such as 3D bioprinting are outlined in the conclusion. This paper aims to encourage further investigation and open up new, disruptive avenues for polysaccharides in wound dressing material development. View Full-Text
Keywords: wound healing; wound dressing; foam; nanofiber; hydrogel; wound management; skin; polysaccharide wound healing; wound dressing; foam; nanofiber; hydrogel; wound management; skin; polysaccharide
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MDPI and ACS Style

Aduba, D.C., Jr.; Yang, H. Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials. Bioengineering 2017, 4, 1.

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