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Bioengineering
Volume 10
Issue 7
10.3390/bioengineering10070849
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Article
Peer-Review Record

Perfusion of MC3T3E1 Preosteoblast Spheroids within Polysaccharide-Based Hydrogel Scaffolds: An Experimental and Numerical Study at the Bioreactor Scale

Bioengineering 2023, 10(7), 849; https://doi.org/10.3390/bioengineering10070849
by Jérôme Grenier 1,2,3, Bertrand David 2,*, Clément Journé 3, Iwona Cicha 4, Didier Letourneur 3,† and Hervé Duval 1,†
Reviewer 1:
Athina Angelopoulou
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Bioengineering 2023, 10(7), 849; https://doi.org/10.3390/bioengineering10070849
Submission received: 30 May 2023 / Revised: 8 July 2023 / Accepted: 13 July 2023 / Published: 18 July 2023
(This article belongs to the Special Issue Bioreactors for Advanced Cell Culture, (Nano)toxicity, Regenerative Medicine and Organ Bioengineering—2nd Edition)

Round 1

Reviewer 1 Report

Manuscript

Title: “Perfusion of MC3T3E1 preosteoblast spheroids within polysaccharide-based hydrogel scaffolds: experimental and numerical study at the bioreactor scale"

Author(s): Jérôme Grenier, Bertrand David, Clément Journé, Iwona Cicha, Didier Letourneur and Hervé Duval

 

Reviewer Comments to Author(s)

Recommendation: Accept

The issues have been addressed and the manuscript can be accepted in the present form

Author Response

Reply in the attached file.

Author Response File: Author Response.docx

Reviewer 2 Report

This manuscript deals with  porous polysaccharide-based hydrogel scaffolds developed in a bioreactor-type perfusion device that generates favorable mechanical stresses while enhancing nutrient transfers.

The authors combined advanced experiments and theory in a unique way and the whole manuscript is impressive. However, this work could be further improved.

POINTS FOR IMPROVEMENT:

1. The abstract could be shorten summarizing the findings of this work.

2. Write a paragraph reporting summarizing applications of this work and directions of future work.

3. Please, add few schemes illustrating  a) the followed experimental methodology of this work b) the experimental set up.

Author Response

Reply in the attached file.

Author Response File: Author Response.docx

Reviewer 3 Report

Review (recommended major revision)

 

This modelling study explores a novel investigation approach to an in vitro tissue engineering process by integrating the external stimuli sensors into 3D culture reactor systems. By using hydrogel template scaffolds, a bioreactor (device) and integration, favorable mechanical loading was achieved.

 

***recommended major revision***

Comments for author File: Comments.pdf

Review (recommended major revision)

 

This modelling study explores a novel investigation approach to an in vitro tissue engineering process by integrating the external stimuli sensors into 3D culture reactor systems. By using hydrogel template scaffolds, a bioreactor (device) and integration, favorable mechanical loading was achieved.

 

***recommended major revision***

Author Response

See the reply in the attached file.

Author Response File: Author Response.docx

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