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Open AccessArticle

Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique

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Department of Chemical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
2
Department of Materials Process Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
*
Author to whom correspondence should be addressed.
ChemEngineering 2018, 2(4), 60; https://doi.org/10.3390/chemengineering2040060
Received: 19 October 2018 / Revised: 28 November 2018 / Accepted: 6 December 2018 / Published: 9 December 2018
Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-HIV, and anti-microbial activity. Recently, electrospraying has been successfully used to produce micro-or nano-sized particles for pharmaceutical use. In this work, polyvinylpyrrolidone (PVP) microspheres containing curcumin were prepared via electrospraying in order to improve the bioavailability of poorly-water-soluble curcumin. The influence of five processing parameters namely curcumin/PVP ratio, tip to collector distance, and electric voltage on physic-chemical properties was investigated. The characterization and aqueous solubility of particles were determined by using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and UV-Vis spectrophotometer. The result indicated that the spherical particles with particle size distribution of 164 to 730 nm obtained at a curcumin/PVP ratio of 1:30, a polymer solution concentration of 0.4%, electric voltage of 10 kV, and a tip-to-collector distance of 15 cm. Moreover, the dissolution of curcumin/PVP particle generated by electrospraying was higher than that of the original curcumin and pure curcumin particles produced by electrospraying. View Full-Text
Keywords: electrospraying; micronization; curcumin; polyvinylpyrrolidone; dissolution electrospraying; micronization; curcumin; polyvinylpyrrolidone; dissolution
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MDPI and ACS Style

Chhouk, K.; Diono, W.; Kanda, H.; Goto, M. Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique. ChemEngineering 2018, 2, 60.

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