Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique
AbstractCurcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-HIV, and anti-microbial activity. Recently, electrospraying has been successfully used to produce micro-or nano-sized particles for pharmaceutical use. In this work, polyvinylpyrrolidone (PVP) microspheres containing curcumin were prepared via electrospraying in order to improve the bioavailability of poorly-water-soluble curcumin. The influence of five processing parameters namely curcumin/PVP ratio, tip to collector distance, and electric voltage on physic-chemical properties was investigated. The characterization and aqueous solubility of particles were determined by using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and UV-Vis spectrophotometer. The result indicated that the spherical particles with particle size distribution of 164 to 730 nm obtained at a curcumin/PVP ratio of 1:30, a polymer solution concentration of 0.4%, electric voltage of 10 kV, and a tip-to-collector distance of 15 cm. Moreover, the dissolution of curcumin/PVP particle generated by electrospraying was higher than that of the original curcumin and pure curcumin particles produced by electrospraying. View Full-Text
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Chhouk, K.; Diono, W.; Kanda, H.; Goto, M. Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique. ChemEngineering 2018, 2, 60.
Chhouk K, Diono W, Kanda H, Goto M. Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique. ChemEngineering. 2018; 2(4):60.Chicago/Turabian Style
Chhouk, Kimthet; Diono, Wahyu; Kanda, Hideki; Goto, Motonobu. 2018. "Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique." ChemEngineering 2, no. 4: 60.
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