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Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique

1
Department of Chemical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
2
Department of Materials Process Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
*
Author to whom correspondence should be addressed.
ChemEngineering 2018, 2(4), 60; https://doi.org/10.3390/chemengineering2040060
Received: 19 October 2018 / Revised: 28 November 2018 / Accepted: 6 December 2018 / Published: 9 December 2018
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Abstract

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-HIV, and anti-microbial activity. Recently, electrospraying has been successfully used to produce micro-or nano-sized particles for pharmaceutical use. In this work, polyvinylpyrrolidone (PVP) microspheres containing curcumin were prepared via electrospraying in order to improve the bioavailability of poorly-water-soluble curcumin. The influence of five processing parameters namely curcumin/PVP ratio, tip to collector distance, and electric voltage on physic-chemical properties was investigated. The characterization and aqueous solubility of particles were determined by using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and UV-Vis spectrophotometer. The result indicated that the spherical particles with particle size distribution of 164 to 730 nm obtained at a curcumin/PVP ratio of 1:30, a polymer solution concentration of 0.4%, electric voltage of 10 kV, and a tip-to-collector distance of 15 cm. Moreover, the dissolution of curcumin/PVP particle generated by electrospraying was higher than that of the original curcumin and pure curcumin particles produced by electrospraying. View Full-Text
Keywords: electrospraying; micronization; curcumin; polyvinylpyrrolidone; dissolution electrospraying; micronization; curcumin; polyvinylpyrrolidone; dissolution
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chhouk, K.; Diono, W.; Kanda, H.; Goto, M. Micronization for Enhancement of Curcumin Dissolution via Electrospraying Technique. ChemEngineering 2018, 2, 60.

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