Next Article in Journal
Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects
Previous Article in Journal
Trends in the Use of Glyphosate Herbicide and Its Relevant Regulations in Taiwan: A Water Contaminant of Increasing Concern
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview

Comparative Overview of the Mechanisms of Action of Hormones and Endocrine Disruptor Compounds

1
CNRS, INRA, Physiologie de la Reproduction & des Comportements, 37380 Nouzilly, France
2
Faculty of Biology-Agricultural Engineering, Quy Nhon University, Binh Dinh 820000, Vietnam
*
Author to whom correspondence should be addressed.
Received: 10 January 2019 / Revised: 21 January 2019 / Accepted: 22 January 2019 / Published: 24 January 2019
(This article belongs to the Section Toxicology and Public Health)
  |  
PDF [921 KB, uploaded 16 February 2019]
  |  

Abstract

Endocrine Disruptor Compounds (EDCs) are synthetic or natural molecules in the environment that promote adverse modifications of endogenous hormone regulation in humans and/or in wildlife animals. In the present paper, we review the potential mechanisms of EDCs and point out the similarities and differences between EDCs and hormones. There was only one mechanism, out of nine identified, in which EDCs acted like hormones (i.e., binding and stimulated hormone receptor activity). In the other eight identified mechanisms of action, EDCs exerted their effects either by affecting endogenous hormone concentration, or its availability, or by modifying hormone receptor turn over. This overview is intended to classify the various EDC mechanisms of action in order to better appreciate when in vitro tests would be valid to assess their risks towards humans and wildlife. View Full-Text
Keywords: endocrine disruptor; hormone; receptor; mechanism; risk assessment endocrine disruptor; hormone; receptor; mechanism; risk assessment
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Combarnous, Y.; Nguyen, T.M.D. Comparative Overview of the Mechanisms of Action of Hormones and Endocrine Disruptor Compounds. Toxics 2019, 7, 5.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxics EISSN 2305-6304 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top