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Comparative Overview of the Mechanisms of Action of Hormones and Endocrine Disruptor Compounds

CNRS, INRA, Physiologie de la Reproduction & des Comportements, 37380 Nouzilly, France
Faculty of Biology-Agricultural Engineering, Quy Nhon University, Binh Dinh 820000, Vietnam
Author to whom correspondence should be addressed.
Received: 10 January 2019 / Revised: 21 January 2019 / Accepted: 22 January 2019 / Published: 24 January 2019
(This article belongs to the Section Toxicology and Public Health)
PDF [921 KB, uploaded 16 February 2019]


Endocrine Disruptor Compounds (EDCs) are synthetic or natural molecules in the environment that promote adverse modifications of endogenous hormone regulation in humans and/or in wildlife animals. In the present paper, we review the potential mechanisms of EDCs and point out the similarities and differences between EDCs and hormones. There was only one mechanism, out of nine identified, in which EDCs acted like hormones (i.e., binding and stimulated hormone receptor activity). In the other eight identified mechanisms of action, EDCs exerted their effects either by affecting endogenous hormone concentration, or its availability, or by modifying hormone receptor turn over. This overview is intended to classify the various EDC mechanisms of action in order to better appreciate when in vitro tests would be valid to assess their risks towards humans and wildlife. View Full-Text
Keywords: endocrine disruptor; hormone; receptor; mechanism; risk assessment endocrine disruptor; hormone; receptor; mechanism; risk assessment

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Combarnous, Y.; Nguyen, T.M.D. Comparative Overview of the Mechanisms of Action of Hormones and Endocrine Disruptor Compounds. Toxics 2019, 7, 5.

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