Next Article in Journal
Propensity of Tagetes erecta L., a Medicinal Plant Commonly Used in Diabetes Management, to Accumulate Perfluoroalkyl Substances
Next Article in Special Issue
The Versatile Roles of the tRNA Epitranscriptome during Cellular Responses to Toxic Exposures and Environmental Stress
Previous Article in Journal
Exploration of Computational Approaches to Predict the Toxicity of Chemical Mixtures
Previous Article in Special Issue
Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases
Open AccessFeature PaperReview

Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
Current address: Gilead Sciences, 333 Lakeside Dr, Foster City, CA 94404, USA.
Toxics 2019, 7(1), 16; https://doi.org/10.3390/toxics7010016
Received: 2 February 2019 / Revised: 9 March 2019 / Accepted: 13 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Biomarkers of Environmental Toxicants)
DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk. We have summarized research conducted since 2012 on DNA adduct formation in smokers. A variety of DNA adducts derived from various classes of carcinogens, including aromatic amines, polycyclic aromatic hydrocarbons, tobacco-specific nitrosamines, alkylating agents, aldehydes, volatile carcinogens, as well as oxidative damage have been reported. The results are discussed with particular attention to the analytical methods used in those studies. Mass spectrometry-based methods that have higher selectivity and specificity compared to 32P-postlabeling or immunochemical approaches are preferred. Multiple DNA adducts specific to tobacco constituents have also been characterized for the first time in vitro or detected in vivo since 2012, and descriptions of those adducts are included. We also discuss common issues related to measuring DNA adducts in humans, including the development and validation of analytical methods and prevention of artifact formation. View Full-Text
Keywords: DNA adducts; tobacco smoke; human carcinogen; biomarkers; cancer risk; mass spectrometry DNA adducts; tobacco smoke; human carcinogen; biomarkers; cancer risk; mass spectrometry
Show Figures

Figure 1

MDPI and ACS Style

Ma, B.; Stepanov, I.; Hecht, S.S. Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke. Toxics 2019, 7, 16.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop