Next Article in Journal / Special Issue
Impact of Maternal Air Pollution Exposure on Children’s Lung Health: An Indian Perspective
Previous Article in Journal
Comparative Assessment of Tungsten Toxicity in the Absence or Presence of Other Metals
Previous Article in Special Issue
Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessArticle
Toxics 2018, 6(4), 67; https://doi.org/10.3390/toxics6040067

Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink

1
Institute of Chronic Illnesses, Inc., 14 Redgate Court, Silver Spring, MD 20905, USA
2
CoMeD, Inc., 14 Redgate Court, Silver Spring, MD 20905, USA
3
CONEM US Autism Research Group, 408 N. Allen Dr., Allen, TX 75013, USA
*
Author to whom correspondence should be addressed.
Received: 11 October 2018 / Revised: 1 November 2018 / Accepted: 10 November 2018 / Published: 15 November 2018
(This article belongs to the Special Issue Prenatal Exposure to Toxics and Risks in Infants)
  |  
PDF [230 KB, uploaded 15 November 2018]

Abstract

Studies suggest a relationship between exposure to endocrine disrupters, such as mercury (Hg), and premature puberty. Hg exposure from Thimerosal-containing hepatitis B vaccine, administered at specific intervals within the first six months of life, and the child’s long-term risk of being diagnosed with premature puberty (ICD-9 code: 259.1), was retrospectively examined, using a hypothesis-testing, longitudinal case-control design on prospectively collected data, in the Vaccine Safety Datalink (VSD). Cases diagnosed with premature puberty were significantly more likely to have received increased exposure to Hg from hepatitis B vaccines preserved with Thimerosal given in the first month after birth (odds ratio (OR) = 1.803), first two months after birth (OR = 1.768), and first six months after birth (OR = 2.0955), compared to control subjects. When the data were separated by gender, the effects remained among females but not males. Female cases, as compared to female controls, were significantly more likely in a dose-dependent manner to have received a greater exposure to Hg from hepatitis B vaccines preserved with Thimerosal, given in the first six months after birth (OR = 1.0281 per µg Hg). The results of this study show a dose-dependent association between increasing organic Hg exposure from Thimerosal-containing hepatitis B vaccines administered within the first six months of life and the long-term risk of the child being diagnosed with premature puberty. View Full-Text
Keywords: ethylmercury; mercury; merthiolate; premature puberty; thiomersal ethylmercury; mercury; merthiolate; premature puberty; thiomersal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Geier, D.A.; Kern, J.K.; Geier, M.R. Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink. Toxics 2018, 6, 67.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxics EISSN 2305-6304 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top