Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression
AbstractMercury compounds are known to cause central nervous system disorders; however the detailed molecular mechanisms of their actions remain unclear. Methylmercury increases the expression of several chemokine genes, specifically in the brain, while metallothionein-III (MT-III) has a protective role against various brain diseases. In this study, we investigated the involvement of MT-III in chemokine gene expression changes in response to methylmercury and mercury vapor in the cerebrum and cerebellum of wild-type mice and MT-III null mice. No difference in mercury concentration was observed between the wild-type mice and MT-III null mice in any brain tissue examined. The expression of Ccl3 in the cerebrum and of Cxcl10 in the cerebellum was increased by methylmercury in the MT-III null but not the wild-type mice. The expression of Ccl7 in the cerebellum was increased by mercury vapor in the MT-III null mice but not the wild-type mice. However, the expression of Ccl12 and Cxcl12 was increased in the cerebrum by methylmercury only in the wild-type mice and the expression of Ccl3 in the cerebellum was increased by mercury vapor only in the wild-type mice. These results indicate that MT-III does not affect mercury accumulation in the brain, but that it affects the expression of some chemokine genes in response to mercury compounds. View Full-Text
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Lee, J.-Y.; Tokumoto, M.; Hwang, G.-W.; Kim, M.-S.; Takahashi, T.; Naganuma, A.; Yoshida, M.; Satoh, M. Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression. Toxics 2018, 6, 48.
Lee J-Y, Tokumoto M, Hwang G-W, Kim M-S, Takahashi T, Naganuma A, Yoshida M, Satoh M. Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression. Toxics. 2018; 6(3):48.Chicago/Turabian Style
Lee, Jin-Yong; Tokumoto, Maki; Hwang, Gi-Wook; Kim, Min-Seok; Takahashi, Tsutomu; Naganuma, Akira; Yoshida, Minoru; Satoh, Masahiko. 2018. "Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression." Toxics 6, no. 3: 48.
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