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Volume 14
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10.3390/toxics14010030
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Article

Lethal and Sublethal Effects of the Novel cis-Nitromethylene Neonicotinoid Cycloxaprid on the Green Peach Aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae)

by
Junshu Zhu
1,2,†,
Li Wang
1,3,†,
Zongyin Cui
1,
Weiling Huang
1,
Qinqin Wang
1,3,
Wenjie Wang
1,2,
Qingjie Yang
1,
Changhui Rui
1 and
Li Cui
1,*
1
Key Laboratory of Integrated Pest Management in Crops, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
2
College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China
3
College of Plant Protection, Henan Agricultural University, Zhengzhou 450002, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Toxics 2026, 14(1), 30; https://doi.org/10.3390/toxics14010030 (registering DOI)
Submission received: 27 November 2025 / Revised: 22 December 2025 / Accepted: 25 December 2025 / Published: 26 December 2025
Versions Notes

Abstract

Myzus persicae is a worldwide insect pest with high resistance to many traditional insecticides. Cycloxaprid, a novel cis-configuration neonicotinoid insecticide, is effective in controlling neonicotinoid-resistant insect pests. Lethal and sublethal effects of cycloxaprid on M. persicae were conducted in this study. Results showed that cycloxaprid had higher toxicity to the laboratory and field resistant M. persicae than imidacloprid. Because of the resistance, imidacloprid showed lower control efficacy (<60%) against M. persicae, which falls short of the efficacy required for practical agricultural management. However, cycloxaprid exhibited higher control efficacies (>84.79%) against M. persicae in the field. In addition, in order to quantify the sublethal impacts of cycloxaprid, we conducted a life table analysis on M. persicae. When resistant M. persicae was treated with LC25 of cycloxaprid or imidacloprid, the longevity and fecundity of F1 adults were significantly decreased. Meanwhile, the intrinsic rate of increase (rm), finite rate of increase (λ) and net reproduction rate (Ri) of F1 generation M. persicae were reduced in cycloxaprid and imidacloprid treatments. Therefore, cycloxaprid shows high potential as a candidate insecticide for managing imidacloprid-resistant M. persicae. Importantly, our laboratory data indicate that exposure to its low sublethal concentration (LC25) inhibits population growth parameters, suggesting a low risk of inducing pest resurgence under such conditions.
Keywords: green peach aphid; cycloxaprid; lethal effect; life table green peach aphid; cycloxaprid; lethal effect; life table

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MDPI and ACS Style

Zhu, J.; Wang, L.; Cui, Z.; Huang, W.; Wang, Q.; Wang, W.; Yang, Q.; Rui, C.; Cui, L. Lethal and Sublethal Effects of the Novel cis-Nitromethylene Neonicotinoid Cycloxaprid on the Green Peach Aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae). Toxics 2026, 14, 30. https://doi.org/10.3390/toxics14010030

AMA Style

Zhu J, Wang L, Cui Z, Huang W, Wang Q, Wang W, Yang Q, Rui C, Cui L. Lethal and Sublethal Effects of the Novel cis-Nitromethylene Neonicotinoid Cycloxaprid on the Green Peach Aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae). Toxics. 2026; 14(1):30. https://doi.org/10.3390/toxics14010030

Chicago/Turabian Style

Zhu, Junshu, Li Wang, Zongyin Cui, Weiling Huang, Qinqin Wang, Wenjie Wang, Qingjie Yang, Changhui Rui, and Li Cui. 2026. "Lethal and Sublethal Effects of the Novel cis-Nitromethylene Neonicotinoid Cycloxaprid on the Green Peach Aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae)" Toxics 14, no. 1: 30. https://doi.org/10.3390/toxics14010030

APA Style

Zhu, J., Wang, L., Cui, Z., Huang, W., Wang, Q., Wang, W., Yang, Q., Rui, C., & Cui, L. (2026). Lethal and Sublethal Effects of the Novel cis-Nitromethylene Neonicotinoid Cycloxaprid on the Green Peach Aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae). Toxics, 14(1), 30. https://doi.org/10.3390/toxics14010030

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