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Article

Head-to-Head Study of Developmental Neurotoxicity and Resultant Phenotype in Rats: α-Hexabromocyclododecane versus Valproic Acid, a Recognized Model of Reference for Autism Spectrum Disorders

1
Calbinotox, EA7488, Université de Lorraine, 54506 Nancy, France
2
Immune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, 29 rue Henri Koch, L-4354 Esch-Sur-Alzette, Luxembourg
3
Inserm U1256, NGERE, Université de Lorraine, 54000 Nancy, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Michael Caudle
Toxics 2022, 10(4), 180; https://doi.org/10.3390/toxics10040180
Received: 21 March 2022 / Revised: 1 April 2022 / Accepted: 4 April 2022 / Published: 6 April 2022
Evidence is now growing that exposure to environmental pollutants during the critical early-life period of brain development may contribute to the emergence of Autism Spectrum Disorders (ASD). This study seeks to compare the developmental neurotoxicity of the α-isomer of hexabromocyclododecane (α-HBCDD), a persistent brominated flame retardant, to the valproic acid (VPA) model of ASD in rodents. Pregnant Wistar rats were divided into three groups: control, α-HBCDD (100 ng/kg/day p.o., GD0-PND21) and VPA (600 mg/kg i.p., GD12). Male offspring were tested for their neuromotor development from PND2-21. At PND21, brain functionality was assessed by measuring cytochrome oxidase activity (CO). Modifications in neuroglia and synaptic plasticity were evaluated in the cortex. Similar subtle behavioural changes related to neuromotor maturation and noise reaction were observed in both treated groups. At PND21, a reduction in CO activity was measured in the VPA group only, in specific areas including auditory nuclei, visual cortex, cingulate and frontal cortices. At the same age, α-HBCDD pointed out significant overexpression of cortical markers of synaptic plasticity while both treated groups showed a significant under expression of astrocyte proteins (S100-β and GFAP). Early-life exposure to a low dose of α-HBCDD may trigger neurobehavioural alterations in line with ASD. View Full-Text
Keywords: α-HBCDD; Autism Spectrum Disorders; early life exposure; brain functionality; neuroglia; synaptic plasticity; neuromotor maturation; noise reaction; rat α-HBCDD; Autism Spectrum Disorders; early life exposure; brain functionality; neuroglia; synaptic plasticity; neuromotor maturation; noise reaction; rat
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MDPI and ACS Style

Morel, C.; Christophe, A.; Maguin-Gaté, K.; Paoli, J.; Turner, J.D.; Schroeder, H.; Grova, N. Head-to-Head Study of Developmental Neurotoxicity and Resultant Phenotype in Rats: α-Hexabromocyclododecane versus Valproic Acid, a Recognized Model of Reference for Autism Spectrum Disorders. Toxics 2022, 10, 180. https://doi.org/10.3390/toxics10040180

AMA Style

Morel C, Christophe A, Maguin-Gaté K, Paoli J, Turner JD, Schroeder H, Grova N. Head-to-Head Study of Developmental Neurotoxicity and Resultant Phenotype in Rats: α-Hexabromocyclododecane versus Valproic Acid, a Recognized Model of Reference for Autism Spectrum Disorders. Toxics. 2022; 10(4):180. https://doi.org/10.3390/toxics10040180

Chicago/Turabian Style

Morel, Chloé, Armelle Christophe, Katy Maguin-Gaté, Justine Paoli, Jonathan David Turner, Henri Schroeder, and Nathalie Grova. 2022. "Head-to-Head Study of Developmental Neurotoxicity and Resultant Phenotype in Rats: α-Hexabromocyclododecane versus Valproic Acid, a Recognized Model of Reference for Autism Spectrum Disorders" Toxics 10, no. 4: 180. https://doi.org/10.3390/toxics10040180

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