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Open AccessArticle

Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage

Department of Chemistry, College of Sciences, University of Hafr Al Batin, P.O. Box 1803, Hafr Al Batin 39524, Saudi Arabia
Laboratoire de Biotechnologie de l’Olivier, Centre de Biotechnologie de Borj-Cedria, B.P.901, Hammam-Lif 2050, Tunisia
Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia
Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, Edificio BioRegión, 18016 Granada, Spain
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax 3018, Tunisia
Author to whom correspondence should be addressed.
Foods 2020, 9(6), 804;
Received: 21 May 2020 / Revised: 11 June 2020 / Accepted: 16 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Isolation and Identification of Bioactive Secondary Metabolites)
Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl4) in rat models. For this purpose, healthy albino rats of 180–250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl4 treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO2 extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl4 treatment. View Full-Text
Keywords: olive leaves; supercritical fluid extraction; antioxidants olive leaves; supercritical fluid extraction; antioxidants
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MDPI and ACS Style

Taamalli, A.; Feriani, A.; Lozano-Sanchez, J.; Ghazouani, L.; El Mufti, A.; Allagui, M.S.; Segura-Carretero, A.; Mhamdi, R.; Arráez-Roman, D. Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage. Foods 2020, 9, 804.

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