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Article

A Review of Registered Clinical Trials on Dietary (Poly)Phenols: Past Efforts and Possible Future Directions

1
Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20133 Milan, Italy
2
CRC “Innovation for Well-Being and Environment (I-WE)”, Università degli Studi di Milano, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Foods 2020, 9(11), 1606; https://doi.org/10.3390/foods9111606
Received: 9 October 2020 / Revised: 29 October 2020 / Accepted: 31 October 2020 / Published: 4 November 2020
In recent years, the increasing number of studies on polyphenol demonstrates the efforts in elucidating the potential role of these bioactives on human health. This study reviews the main topics and characteristics of clinical trials on polyphenols registered over the last 20 years, in order to track past and current efforts as well as to highlight the main research gaps in this field. The review was conducted by collecting trials registered in ClinicalTrials.gov and International Standard Randomised Controlled Trial Number (ISRCTN) registry. Overall, 750 clinical trials were selected and included in the final evaluation. Most of the trials were performed on extracts or pure compounds followed by studies conducted on polyphenol-rich foods, in particular berries. A total of 520 clinical trials focused on health effects, 55 on bioavailability, and 175 on both. Regarding outcomes, 139 registered intervention studies had the lipid profile and blood pressure as primary outcomes. The overview provided by this analysis also emphasizes the emerging interest in new outcomes related to polyphenols intervention such as microbiota composition and the evaluation of inter-individual variability in response to the intake of polyphenols. Our review underlines the need of further trials covering unexplored or debated research aspects and provides insights for the design and development of future intervention studies and related research areas. View Full-Text
Keywords: bioactive compounds; clinical trials; human nutrition; health outcomes; food; food extracts bioactive compounds; clinical trials; human nutrition; health outcomes; food; food extracts
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MDPI and ACS Style

Marino, M.; Del Bo’, C.; Martini, D.; Porrini, M.; Riso, P. A Review of Registered Clinical Trials on Dietary (Poly)Phenols: Past Efforts and Possible Future Directions. Foods 2020, 9, 1606. https://doi.org/10.3390/foods9111606

AMA Style

Marino M, Del Bo’ C, Martini D, Porrini M, Riso P. A Review of Registered Clinical Trials on Dietary (Poly)Phenols: Past Efforts and Possible Future Directions. Foods. 2020; 9(11):1606. https://doi.org/10.3390/foods9111606

Chicago/Turabian Style

Marino, Mirko, Cristian Del Bo’, Daniela Martini, Marisa Porrini, and Patrizia Riso. 2020. "A Review of Registered Clinical Trials on Dietary (Poly)Phenols: Past Efforts and Possible Future Directions" Foods 9, no. 11: 1606. https://doi.org/10.3390/foods9111606

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