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Article

Non-Viable Lactobacillus johnsonii JNU3402 Protects against Diet-Induced Obesity

1
Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju 61186, Korea
2
Division of Animal Science, College of Agriculture & Life Sciences, Chonnam National University, Gwangju 61186, Korea
*
Authors to whom correspondence should be addressed.
Foods 2020, 9(10), 1494; https://doi.org/10.3390/foods9101494
Received: 7 September 2020 / Revised: 9 October 2020 / Accepted: 15 October 2020 / Published: 19 October 2020
(This article belongs to the Special Issue The Application of Microorganisms in Food Processing)
In this study, the role of non-viable Lactobacillus johnsonii JNU3402 (NV-LJ3402) in diet-induced obesity was investigated in mice fed a high-fat diet (HFD). To determine whether NV-LJ3402 exhibits a protective effect against diet-induced obesity, 7-week-old male C57BL/6J mice were fed a normal diet, an HFD, or an HFD with NV-LJ3402 for 14 weeks. NV-LJ3402 administration was associated with a significant reduction in body weight gain and in liver, epididymal, and inguinal white adipose tissue (WAT) and brown adipose tissue weight in HFD-fed mice. Concomitantly, NV-LJ3402 administration to HFD-fed mice also decreased the triglyceride levels in the plasma and metabolic tissues and slightly improved insulin resistance. Furthermore, NV-LJ3402 enhanced gene programming for energy dissipation in the WATs of HFD-fed mice as well as in 3T3-L1 adipocytes with increased peroxisome proliferator-activated receptor-γ (PPARγ) transcriptional activity, suggesting that the PPARγ pathway plays a key role in mediating the anti-obesity effect of NV-LJ3402 in HFD-fed mice. Furthermore, NV-LJ3402 administration in HFD-fed mice enhanced mitochondrial levels and function in WATs and also increased the body temperature upon cold exposure. Together, these results suggest that NV-LJ3402 could be safely used to develop dairy products that ameliorate diet-induced obesity and hyperlipidemia. View Full-Text
Keywords: non-viable Lactobacillus johnsonii JNU3402; diet-induced obesity; peroxisome proliferator-associated receptor-γ; body temperature non-viable Lactobacillus johnsonii JNU3402; diet-induced obesity; peroxisome proliferator-associated receptor-γ; body temperature
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MDPI and ACS Style

Yang, G.; Hong, E.; Oh, S.; Kim, E. Non-Viable Lactobacillus johnsonii JNU3402 Protects against Diet-Induced Obesity. Foods 2020, 9, 1494. https://doi.org/10.3390/foods9101494

AMA Style

Yang G, Hong E, Oh S, Kim E. Non-Viable Lactobacillus johnsonii JNU3402 Protects against Diet-Induced Obesity. Foods. 2020; 9(10):1494. https://doi.org/10.3390/foods9101494

Chicago/Turabian Style

Yang, Garam, Eunjeong Hong, Sejong Oh, and Eungseok Kim. 2020. "Non-Viable Lactobacillus johnsonii JNU3402 Protects against Diet-Induced Obesity" Foods 9, no. 10: 1494. https://doi.org/10.3390/foods9101494

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