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The Effect of In Vitro Digestion on Antioxidant, ACE-Inhibitory and Antimicrobial Potentials of Traditional Serbian White-Brined Cheeses

Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11081 Belgrade, Serbia
Maize Research Institute, Slobodana Bajica 1, 11081 Belgrade, Serbia
Institute for Biological Research “Sinisa Stankovic”, University of Belgrade, 11000 Belgrade, Serbia
Author to whom correspondence should be addressed.
Foods 2019, 8(3), 94;
Received: 12 February 2019 / Revised: 1 March 2019 / Accepted: 7 March 2019 / Published: 12 March 2019
(This article belongs to the Section Food Physics and (Bio)Chemistry)
PDF [521 KB, uploaded 13 March 2019]


This study deals with the effect of in vitro digestion on the functional potential of traditional Serbian white-brined cheeses. The total antioxidant capacity, reducing power and iron (II) chelating properties as well as angiotensin-converting enyzme-inhibitory (ACE-inhibitory) and antimicrobial activities of traditional Serbian white-brined cheeses before and after in vitro digestion were assayed. The traditional cheeses had different antioxidant properties as well as different ACE-inhibitory activities. In vitro digestion improved the total antioxidant capacity (8.42–58.56 times) and the reducing power (by 17.90–99.30%) of investigated cheeses, whereas their chelating ability was slightly improved or unaffected after digestion. In vitro digestion reduced the ACE-inhibitory potential of water-soluble protein fractions, and digested water-insoluble fractions were the major source of ACE-inhibitory peptides. The digestates did not exhibit any antibacterial potential, whereas they showed moderate antifungal potential toward selected micromycetes. The best antifungal potential had Svrljig ovine cheese and Homolje cow cheese. The results of this study clearly point to a significant functionality of traditional white-brined cheeses. View Full-Text
Keywords: white-brined cheeses; in vitro digestion; functionality white-brined cheeses; in vitro digestion; functionality

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Barac, M.; Vucic, T.; Zilic, S.; Pesic, M.; Sokovic, M.; Petrovic, J.; Kostic, A.; Sredovic Ignjatovic, I.; Milincic, D. The Effect of In Vitro Digestion on Antioxidant, ACE-Inhibitory and Antimicrobial Potentials of Traditional Serbian White-Brined Cheeses. Foods 2019, 8, 94.

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