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Foods 2018, 7(9), 145; https://doi.org/10.3390/foods7090145

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

1
Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain
2
CIBER de Enfermedades Raras & IBIMA, Instituto de Salud Carlos III, 29010 Málaga, Spain
*
Author to whom correspondence should be addressed.
Received: 1 August 2018 / Revised: 22 August 2018 / Accepted: 29 August 2018 / Published: 4 September 2018
(This article belongs to the Special Issue Biogenic Amines on Food Safety)
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Abstract

Biogenic amines derived from basic and aromatic amino acids (B/A-BAs), polyamines, histamine, serotonin, and catecholamines are a group of molecules playing essential roles in many relevant physiological processes, including cell proliferation, immune response, nutrition and reproduction. All these physiological effects involve a variety of tissue-specific cellular receptors and signalling pathways, which conforms to a very complex network that is not yet well-characterized. Strong evidence has proved the importance of this group of molecules in the gastrointestinal context, also playing roles in several pathologies. This work is based on the hypothesis that integration of biomedical information helps to reach new translational actions. Thus, the major aim of this work is to combine scientific knowledge on biomolecules, metabolism and physiology of the main B/A-BAs involved in the pathophysiology of the gastrointestinal tract, in order to point out important gaps in information and other facts deserving further research efforts in order to connect molecular information with pathophysiological observations. View Full-Text
Keywords: histamine; serotonin; catecholamines; polyamines; gastrointestinal tract; nutrition; inflammation; gastric cancer; bowel diseases; colon cancer histamine; serotonin; catecholamines; polyamines; gastrointestinal tract; nutrition; inflammation; gastric cancer; bowel diseases; colon cancer
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Fernández-Reina, A.; Urdiales, J.L.; Sánchez-Jiménez, F. What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract. Foods 2018, 7, 145.

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