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Review

Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review

1
Department of Elderly Care, Health Care Services Vocational School, Recep Tayyip Erdoğan University, Rize 53100, Türkiye
2
Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Türkiye
3
Department of Nutrition and Dietetics, Faculty of Health Sciences, Recep Tayyip Erdoğan University, Rize 53100, Türkiye
*
Authors to whom correspondence should be addressed.
Foods 2025, 14(23), 4133; https://doi.org/10.3390/foods14234133
Submission received: 29 October 2025 / Revised: 25 November 2025 / Accepted: 26 November 2025 / Published: 2 December 2025
(This article belongs to the Special Issue Risk Assessment in Food Safety)

Abstract

Foodborne chemical exposure is a significant public health concern. Various chemical agents found in foods, including pesticide residues, heavy metals, natural toxins, compounds formed during food processing, and food additives, may result in carcinogenic or noncarcinogenic health effects in the long term. Along with discussing the main sources of dietary chemical exposure and its health impacts, this review article also covers the theoretical foundations and four main steps of chemical risk assessment. Furthermore, risk assessment approaches are investigated in the light of international organizations and guidelines, and the current debates and challenges within the field are underscored. Lastly, suggestions for safer food supply and potential future developments are presented. This comprehensive review may provide a current literature-based viewpoint on comprehending and addressing dietary chemical-associated public health issues.
Keywords: food safety; chemical exposure; health risk assessment; carcinogenic; noncarcinogenic food safety; chemical exposure; health risk assessment; carcinogenic; noncarcinogenic

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MDPI and ACS Style

Pekmezci, H.; Sipahi, S.; Başaran, B. Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review. Foods 2025, 14, 4133. https://doi.org/10.3390/foods14234133

AMA Style

Pekmezci H, Sipahi S, Başaran B. Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review. Foods. 2025; 14(23):4133. https://doi.org/10.3390/foods14234133

Chicago/Turabian Style

Pekmezci, Hilal, Simge Sipahi, and Burhan Başaran. 2025. "Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review" Foods 14, no. 23: 4133. https://doi.org/10.3390/foods14234133

APA Style

Pekmezci, H., Sipahi, S., & Başaran, B. (2025). Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review. Foods, 14(23), 4133. https://doi.org/10.3390/foods14234133

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