Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials and Reagents
2.2. Animal Experimental Design
2.3. Biochemical Analysis
2.4. Analysis of Enzyme Contents Related to Fatty Acid Oxidation
2.5. Histological Investigation
2.6. Analysis of Hepatic Fatty Acid Composition and Content
2.7. Western Blot Analysis
2.8. Statistical Analysis
3. Results
3.1. Effects of HPSIDF on Body Weight, Food Intake and Fat Accumulation in HFD-Fed Mice
3.2. Effects of HPSIDF on Serum Biochemical Indicators in HFD-Fed Mice
3.3. Effects of HPSIDF on Hepatic Steatosis in HFD-Fed Mice
3.4. Effects of HPSIDF on the Activity of Enzymes Related to Hepatic Fatty Acid Oxidation and the Production of Intermediate and Final Products in HFD-Fed Mice
3.5. Effects of HPSIDF on Hepatic Fatty Acid Content and Composition in HFD-Fed Mice
3.6. Effects of HPSIDF on the Expression Levels of Hepatic Fatty Acid β-Oxidation-Associated Proteins in HFD-Fed Mice
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Items | ND | HFD | HPSIDF | PC |
---|---|---|---|---|
Initial body weight (g) | 20.02 ± 0.93 | 20.80 ± 1.19 | 21.10 ± 1.04 | 21.45 ± 0.63 |
Final body weight (g) | 27.49 ± 2.09 b | 31.78 ± 2.77 a | 26.90 ± 2.79 b | 28.96 ± 2.24 b |
Body weight gain (g) | 7.47 ± 1.40 b | 10.98 ± 2.94 a | 5.99 ± 2.40 c | 7.50 ± 2.57 b |
Food intake (g) | 2.13 ± 0.10 b | 2.47 ± 0.04 a | 2.08 ± 0.07 b | 2.15 ± 0.13 b |
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Zhang, J.; Wang, S.; Wang, J.; Liu, W.; Gong, H.; Zhang, Z.; Lyu, B.; Yu, H. Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation. Foods 2023, 12, 2081. https://doi.org/10.3390/foods12102081
Zhang J, Wang S, Wang J, Liu W, Gong H, Zhang Z, Lyu B, Yu H. Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation. Foods. 2023; 12(10):2081. https://doi.org/10.3390/foods12102081
Chicago/Turabian StyleZhang, Jiarui, Sainan Wang, Junyao Wang, Wenhao Liu, Hao Gong, Zhao Zhang, Bo Lyu, and Hansong Yu. 2023. "Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation" Foods 12, no. 10: 2081. https://doi.org/10.3390/foods12102081