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10.3390/foods11233941
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Review

A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities

by
Xiaoxuan Jing
1,
Jingxuan Zhou
1,
Nanhai Zhang
1,
Liang Zhao
2,
Shiran Wang
1,
Liebing Zhang
1,* and
Feng Zhou
1,*
1
Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2
Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China
*
Authors to whom correspondence should be addressed.
Foods 2022, 11(23), 3941; https://doi.org/10.3390/foods11233941
Submission received: 5 October 2022 / Revised: 30 November 2022 / Accepted: 2 December 2022 / Published: 6 December 2022
(This article belongs to the Special Issue Latest Advances and Prospects into Sources and Potential Applications of Antioxidants, Bioactive and (Poly)Phenolic Compounds in Foods)
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Abstract

Chronic diseases, including metabolic syndrome related to sugar and lipid metabolic disorders, are the leading causes of premature death around the world. Novel treatment strategies without undesirable effects are urgently needed. As a natural functional ingredient, puerarin is a promising alternative for the treatment of sugar and lipid metabolic disorders. However, the applications of puerarin are limited due to its poor solubility and short half-life. Various drug delivery systems have been investigated to improve the bioavailability of puerarin. This review summarizes the mechanisms involved in the beneficial action of puerarin: suppressing the release of glucose and FFA; regulating the transport of glucose and fatty acids; acting on the PI3K–Akt and AMPK signaling pathways to decrease the synthesis of glucose and fatty acids; acting on the PPAR signaling pathway to promote β-oxidation; and improving insulin secretion and sensitivity. In addition, the preparation technologies used to improve the bioavailability of puerarin are also summarized in this review, in the hope of helping to promote the application of puerarin.
Keywords: puerarin; sugar metabolism; lipid metabolism; metabolic syndrome; bioavailability puerarin; sugar metabolism; lipid metabolism; metabolic syndrome; bioavailability

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MDPI and ACS Style

Jing, X.; Zhou, J.; Zhang, N.; Zhao, L.; Wang, S.; Zhang, L.; Zhou, F. A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities. Foods 2022, 11, 3941. https://doi.org/10.3390/foods11233941

AMA Style

Jing X, Zhou J, Zhang N, Zhao L, Wang S, Zhang L, Zhou F. A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities. Foods. 2022; 11(23):3941. https://doi.org/10.3390/foods11233941

Chicago/Turabian Style

Jing, Xiaoxuan, Jingxuan Zhou, Nanhai Zhang, Liang Zhao, Shiran Wang, Liebing Zhang, and Feng Zhou. 2022. "A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities" Foods 11, no. 23: 3941. https://doi.org/10.3390/foods11233941

APA Style

Jing, X., Zhou, J., Zhang, N., Zhao, L., Wang, S., Zhang, L., & Zhou, F. (2022). A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities. Foods, 11(23), 3941. https://doi.org/10.3390/foods11233941

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