Next Article in Journal
Neuroorganoleptics: Organoleptic Testing Based on Psychophysiological Sensing
Next Article in Special Issue
Ethanol-Induced Hepatotoxicity and Alcohol Metabolism Regulation by GABA-Enriched Fermented Smilax china Root Extract in Rats
Previous Article in Journal
Improving the Storability of Cod Fish-Burgers According to the Zero-Waste Approach
Previous Article in Special Issue
Anti-Obesity Effects of Morus alba L. and Aronia melanocarpa in a High-Fat Diet-Induced Obese C57BL/6J Mouse Model
Article

AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling

1
Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju 27478, Korea
2
Department of Food Science and Nutrition, College of Health Science, Dong-A University, Busan 49315, Korea
3
Center for Silver-Targeted Biomaterials, Brain Busan 21 Plus Program, Dong-A University, Busan 49315, Korea
4
School of Life Sciences, Changchun University of Science and Technology, Changchun 130600, China
5
Gyeongnam Agricultural Research and Extension Services, Jinju 52733, Korea
6
Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Rotimi Aluko
Foods 2021, 10(9), 1973; https://doi.org/10.3390/foods10091973
Received: 16 July 2021 / Revised: 20 August 2021 / Accepted: 21 August 2021 / Published: 24 August 2021
In this study, we investigated the anti-obesity properties of the novel peptide Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg (AGL9), isolated from the enzymatic hydrolysate of Allomyrinadichotoma larvae. To investigate the preventive effects of AGL9 against hepatic steatosis and its possible mechanisms of action, we established an nonalcoholic fatty liver disease (NAFLD) model by feeding C57BL/6 mice a high-fat diet. NAFLD mice were administered 100 mg/kg AGL9 and 60 mg/kg orlistat via gavage (10 mL/kg) for 5 weeks, followed by the collection of blood and liver tissues. We found that AGL9 normalized the levels of serum alanine aminotransferase, aspartate aminotransferase, triglyceride, total cholesterol, high-density lipoprotein, very low-density lipoprotein (LDL)/LDL, adiponectin, and leptin in these mice. Additionally, AGL9 activated the protein-level expression of 5′ AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation and the transcript-level expression of sterol regulatory element-binding protein-1c, fatty acid synthase, superoxide dismutase, glutathione peroxidase, glucocorticoid receptor, nuclear respiratory factor 2, tumor necrosis factor-α, interleukin-1β, interleukin-6, and monocyte chemoattractant protein-1 in hepatocytes. These results showed that AGL9 exhibited hepatoprotective effects by attenuating lipid deposition, oxidative stress, and inflammation via inhibition of AMPK/Nrf2 signaling, thereby reducing the production of hepatic proinflammatory mediators and indicating AGL9 as a potential therapeutic strategy for NAFLD. View Full-Text
Keywords: hepatoprotective peptide; AGL9; hepatic lipid metabolism; inflammation; nonalcoholic fatty liver disease hepatoprotective peptide; AGL9; hepatic lipid metabolism; inflammation; nonalcoholic fatty liver disease
Show Figures

Graphical abstract

MDPI and ACS Style

Fan, M.; Choi, Y.-J.; Tang, Y.; Kim, J.H.; Kim, B.-g.; Lee, B.; Bae, S.M.; Kim, E.-K. AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling. Foods 2021, 10, 1973. https://doi.org/10.3390/foods10091973

AMA Style

Fan M, Choi Y-J, Tang Y, Kim JH, Kim B-g, Lee B, Bae SM, Kim E-K. AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling. Foods. 2021; 10(9):1973. https://doi.org/10.3390/foods10091973

Chicago/Turabian Style

Fan, Meiqi, Young-Jin Choi, Yujiao Tang, Ji H. Kim, Byung-gyu Kim, Bokyung Lee, Sung M. Bae, and Eun-Kyung Kim. 2021. "AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling" Foods 10, no. 9: 1973. https://doi.org/10.3390/foods10091973

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop