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Article

Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets

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Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2
Healthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agricultural, Albany, CA 94710, USA
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Foodborne Toxins Detection and Prevention Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA 94710, USA
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Nestlé R & D (China) Ltd., Beijing 100015, China
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Key Research Laboratory of Agro-Products Processing, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China
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Experimental Seafood Processing Laboratory, Costal Research and Extension Center, Mississippi State University, Starkville, MS 39567, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alberto Cepeda Sáez
Foods 2021, 10(8), 1691; https://doi.org/10.3390/foods10081691
Received: 15 June 2021 / Revised: 7 July 2021 / Accepted: 19 July 2021 / Published: 22 July 2021
(This article belongs to the Section Food Nutrition)
Colored common beans are associated with health promoting and chronic disease prevention effects. Male C57BL/6J mice were fed high-fat (HF) diets supplemented with cooked black turtle beans (HFB) to prevent obesity related insulin resistance. Mice on both HF and HFB were obese compared to mice fed a low-fat (LF) diet. Plasma low density lipoprotein (LDL) and triglyceride concentrations of mice fed HFB diet were 28% and 36.6% lower than those on HF diet. Homeostatic model assessment of insulin resistance (HOMA-IR) index of mice fed HFB diet was 87% lower than that of mice fed HF diet. Diabetes related biomarkers, gastric inhibitory polypeptide (GIP), leptin, glucagon, and inflammatory cytokines interleukin 4 (IL-4) and IL-5, 10 and 12, IFN-g and TNF-α were significantly affected by HFB diet. Pparα, Cyp7a1 and Fasn were down-regulated by HFB diet while LDL-R, Srebp-2, Adipoq and Slc2a4 were up-regulated by HFB diet. The ratio of Firmicutes/Bacteroidetes (F/B) was also decreased 64.1% by HFB diet compared to HF diet. The results indicated that cooked black turtle bean consumption could ameliorate insulin resistance and lower plasma LDL in mice fed HF diet through glucose signaling pathway and JNK/c-Jun pathway. Meanwhile, cooked black turtle bean consumption restored the gut microbiome. View Full-Text
Keywords: cooked black turtle bean; insulin resistance; LDL; gut microbiome cooked black turtle bean; insulin resistance; LDL; gut microbiome
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MDPI and ACS Style

Tan, Y.; Tam, C.C.; Meng, S.; Zhang, Y.; Alves, P.; Yokoyama, W. Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets. Foods 2021, 10, 1691. https://doi.org/10.3390/foods10081691

AMA Style

Tan Y, Tam CC, Meng S, Zhang Y, Alves P, Yokoyama W. Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets. Foods. 2021; 10(8):1691. https://doi.org/10.3390/foods10081691

Chicago/Turabian Style

Tan, Yuqing, Christina C. Tam, Shi Meng, Yan Zhang, Priscila Alves, and Wallace Yokoyama. 2021. "Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets" Foods 10, no. 8: 1691. https://doi.org/10.3390/foods10081691

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