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Article

Effects of Neohesperidin Dihydrochalcone (NHDC) on Oxidative Phosphorylation, Cytokine Production, and Lipid Deposition

1
Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Korea
2
Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Kwang-Geun Lee
Foods 2021, 10(6), 1408; https://doi.org/10.3390/foods10061408
Received: 29 April 2021 / Revised: 10 June 2021 / Accepted: 15 June 2021 / Published: 18 June 2021
The sweetener neohesperidin dihydrochalcone (NHDC) is a precursor for anthocyanins and has been reported to have various bioactivities, including antioxidant and hepatitis inhibitory effects. However, its inflammatory functions and mechanisms of action are poorly understood. In this study, RAW 264.7 murine macrophages were treated with NHDC and its metabolite dihydrocaffeic acid (DHCA), after which cytokine production and mitochondrial respiration were assessed. DHCA significantly down-regulated the secretion of pro-inflammatory cytokines. In contrast, NHDC had a marginal effect, suggesting that the biological metabolism of NHDC to DHCA is required for its anti-inflammatory function. However, both NHDC and DHCA rescued LPS-induced suppression of oxidative phosphorylation, which is a hallmark of anti-inflammatory M2 macrophages. 3T3-L1 adipocytes showed lower fat deposition in the presence of DHCA, while sugar-containing NHDC showed a slight increase in fat deposition. In high-fat diet-induced obese mice, treatment with NHDC successfully down-regulated body weight gain in a dose-dependent manner. Furthermore, M2 polarized bone-marrow-derived macrophages (BMDM) from NHDC-fed mice secreted an increased amount of the anti-inflammatory cytokine IL-10. Overall, these results indicate that NHDC and its physiological metabolite DHCA have the potential to suppress the inflammatory response and obese status. View Full-Text
Keywords: NHDC; chalcone; inflammation; obesity; lipid NHDC; chalcone; inflammation; obesity; lipid
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MDPI and ACS Style

Choi, S.; Yu, S.; Lee, J.; Kim, W. Effects of Neohesperidin Dihydrochalcone (NHDC) on Oxidative Phosphorylation, Cytokine Production, and Lipid Deposition. Foods 2021, 10, 1408. https://doi.org/10.3390/foods10061408

AMA Style

Choi S, Yu S, Lee J, Kim W. Effects of Neohesperidin Dihydrochalcone (NHDC) on Oxidative Phosphorylation, Cytokine Production, and Lipid Deposition. Foods. 2021; 10(6):1408. https://doi.org/10.3390/foods10061408

Chicago/Turabian Style

Choi, Sooyeon, Seungmin Yu, Jonghun Lee, and Wooki Kim. 2021. "Effects of Neohesperidin Dihydrochalcone (NHDC) on Oxidative Phosphorylation, Cytokine Production, and Lipid Deposition" Foods 10, no. 6: 1408. https://doi.org/10.3390/foods10061408

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