Next Article in Journal
A Mathematical Modeling of Freezing Process in the Batch Production of Ice Cream
Next Article in Special Issue
Enzyme-Assisted Extraction of Fish Oil from Whole Fish and by-Products of Baltic Herring (Clupea harengus membras)
Previous Article in Journal
Self-Reported Emotions and Facial Expressions on Consumer Acceptability: A Study Using Energy Drinks
 
 
Article

The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats

1
Functional Nutrition, Oxidation and Cardiovascular Disease Research Group (NFOC-SALUT), Pharmacology Unit, Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain
2
Institute of Marine Research (IIM-CSIC), C/Eduardo Cabello 6, 36208 Vigo, Spain
3
Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C/Jordi Girona 18-26, 08034 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Current Address: Department of Cell Biology, Physiology & Immunology, Faculty of Biology, University of Barcelona, Avd/Diagonal 643, 08028 Barcelona, Spain.
Academic Editor: Diana Ansorena Artieda
Foods 2021, 10(2), 332; https://doi.org/10.3390/foods10020332
Received: 22 December 2020 / Revised: 18 January 2021 / Accepted: 1 February 2021 / Published: 4 February 2021
(This article belongs to the Special Issue Functional Lipids in Marine Food)
The combined supplementation of buckwheat D-fagomine (FG) and fish omega-3 polyunsaturated fatty acids (ω-3 PUFA) attenuates the development of insulin resistance in rats fed a high-fat (HF) diet. This study aimed to examine the effects of combined supplementation with FG and ω-3 PUFA on dyslipidemia, transaminases, interleukin-6, and oxidative stress. Forty-five male Sprague-Dawley rats were fed a standard diet, an HF diet, an HF diet supplemented with FG, an HF diet supplemented with ω-3 PUFA, or an HF diet supplemented with FG and ω-3 PUFA for 21 weeks. Triacylglycerol, cholesterol, aspartate aminotransferase, alanine aminotransferase, and interleukin-6 were measured. The assessment of oxidative stress included plasma antioxidant capacity, antioxidant enzyme activities, glutathione content, lipid peroxidation, and protein carbonylation. The combined supplementation with FG and ω-3 PUFA did not attenuate the slight accumulation of liver cholesterol induced by the HF diet but normalized the plasma alanine aminotransferase activity. Rats fed the HF diet supplemented with the combination showed a lower amount of plasma interleukin-6 than those fed a standard diet. The combination attenuated oxidative damage induced by the HF diet, decreased antioxidant enzyme activities, and enhanced glutathione status. The beneficial effects of the combination of FG and ω-3 PUFA on oxidative stress and related risk factors in pre-obese rats were mainly modulated by ω-3 PUFA. View Full-Text
Keywords: D-fagomine; fish oil; dyslipidemia; transaminases; inflammation; oxidative stress D-fagomine; fish oil; dyslipidemia; transaminases; inflammation; oxidative stress
Show Figures

Graphical abstract

MDPI and ACS Style

Miralles-Pérez, B.; Nogués, M.R.; Sánchez-Martos, V.; Taltavull, N.; Méndez, L.; Medina, I.; Ramos-Romero, S.; Torres, J.L.; Romeu, M. The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats. Foods 2021, 10, 332. https://doi.org/10.3390/foods10020332

AMA Style

Miralles-Pérez B, Nogués MR, Sánchez-Martos V, Taltavull N, Méndez L, Medina I, Ramos-Romero S, Torres JL, Romeu M. The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats. Foods. 2021; 10(2):332. https://doi.org/10.3390/foods10020332

Chicago/Turabian Style

Miralles-Pérez, Bernat, Maria Rosa Nogués, Vanessa Sánchez-Martos, Núria Taltavull, Lucía Méndez, Isabel Medina, Sara Ramos-Romero, Josep L. Torres, and Marta Romeu. 2021. "The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats" Foods 10, no. 2: 332. https://doi.org/10.3390/foods10020332

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop