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Volume 9
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10.3390/dj9040041
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Article

Efficacy of EDTA and HEDP Chelators in the Removal of Mature Biofilm of Enterococcus faecalis by PUI and XPF File Activation

by
Alejandro Álvarez-Sagües
1,*,
Nerea Herce
1,
Ulises Amador
2,
Francisco Llinares-Pinel
3,
Estanislao Nistal-Villan
3,
Jesús Presa
4,
Laura Álvarez
1,* and
Magdalena Azabal
1
1
Dentistry Department, Faculty of Medicine, San Pablo CEU University, 28668 Madrid, Spain
2
Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, Urbanización Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain
3
Microbiology Section, Departamento CC, Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU San Pablo, Boadilla del Monte, 28668 Madrid, Spain
4
Independent Researcher, 28668 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Dent. J. 2021, 9(4), 41; https://doi.org/10.3390/dj9040041
Submission received: 7 March 2021 / Revised: 1 April 2021 / Accepted: 6 April 2021 / Published: 9 April 2021
(This article belongs to the Section Dental Materials)
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Abstract

Background: Biofilm removal from the root canal during endodontic treatment is necessary to prevent further complications. Irrigation is essential to success. Several irrigants have been proposed without a proper comparison. The aim of the study is to compare the antibacterial capacity of different activated irrigants using passive ultrasonic activation (PUI) or XP-Endo finisher (XPF). Methods: A total of 100 instrumented teeth were incubated in an Eppendorf tube containing 0.5 McFarland of Enterococcus faecalis and incubated for 2 weeks at 37 °C. Roots were divided into 5 groups (n = 20) according to the irrigant type: ethylenediaminetetraacetic acid (EDTA) (17%), ethydronic acid (HEDP) (9%) mixed with 5.25% sodium hypochlorite (NaOCl), EDTA (17%) mixed with 5.25% NaOCl, PBS, and a control group. Each group was divided into two subgroups (n = 10): PUI and XPF. Results: As compared to the untreated control group, the irrigators included in the study had a significant effect in bacteria reduction. The obtained results show HEDP to be the most effective irrigant, since no bacteria were recovered after treatment of this group, followed by EDTA mixed with NaOCl and, finally, the EDTA-irrigated group. Conclusions: HEDP is the best irrigating agent in combination with XPF or PUI file activation to eliminate bacteria in our experimental model.
Keywords: Enterococcus faecalis; EDTA; ethydronic acid (HEDP); passive ultrasonic activation (PUI); Endo-XP finisher (XPF) Enterococcus faecalis; EDTA; ethydronic acid (HEDP); passive ultrasonic activation (PUI); Endo-XP finisher (XPF)

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MDPI and ACS Style

Álvarez-Sagües, A.; Herce, N.; Amador, U.; Llinares-Pinel, F.; Nistal-Villan, E.; Presa, J.; Álvarez, L.; Azabal, M. Efficacy of EDTA and HEDP Chelators in the Removal of Mature Biofilm of Enterococcus faecalis by PUI and XPF File Activation. Dent. J. 2021, 9, 41. https://doi.org/10.3390/dj9040041

AMA Style

Álvarez-Sagües A, Herce N, Amador U, Llinares-Pinel F, Nistal-Villan E, Presa J, Álvarez L, Azabal M. Efficacy of EDTA and HEDP Chelators in the Removal of Mature Biofilm of Enterococcus faecalis by PUI and XPF File Activation. Dentistry Journal. 2021; 9(4):41. https://doi.org/10.3390/dj9040041

Chicago/Turabian Style

Álvarez-Sagües, Alejandro, Nerea Herce, Ulises Amador, Francisco Llinares-Pinel, Estanislao Nistal-Villan, Jesús Presa, Laura Álvarez, and Magdalena Azabal. 2021. "Efficacy of EDTA and HEDP Chelators in the Removal of Mature Biofilm of Enterococcus faecalis by PUI and XPF File Activation" Dentistry Journal 9, no. 4: 41. https://doi.org/10.3390/dj9040041

APA Style

Álvarez-Sagües, A., Herce, N., Amador, U., Llinares-Pinel, F., Nistal-Villan, E., Presa, J., Álvarez, L., & Azabal, M. (2021). Efficacy of EDTA and HEDP Chelators in the Removal of Mature Biofilm of Enterococcus faecalis by PUI and XPF File Activation. Dentistry Journal, 9(4), 41. https://doi.org/10.3390/dj9040041

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