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Article

The Anchorage of Bone Cells onto an Yttria-Stabilized Zirconia Surface with Mild Nano-Micro Curved Profiles

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Department of Cell Biology, University Medical Center Rostock, D-18057 Rostock, Germany
2
Medical Biology and Electron Microscopic Center, University Medical Center Rostock, D-18057 Rostock, Germany
3
VITA Zahnfabrik H. Rauter GmbH & Co. KG, D-79713 Bad Säckingen, Germany
*
Author to whom correspondence should be addressed.
Dent. J. 2020, 8(4), 127; https://doi.org/10.3390/dj8040127
Received: 5 October 2020 / Revised: 4 November 2020 / Accepted: 6 November 2020 / Published: 10 November 2020
(This article belongs to the Section Dental Materials)
The high biocompatibility, good mechanical properties, and perfect esthetics of ceramic dental materials motivate investigation into their suitability as an endosseous implant. Osseointegration at the interface between bone and implant surface, which is a criterion for dental implant success, is dependent on surface chemistry and topography. We found out earlier that osteoblasts on sharp-edged micro-topographies revealed an impaired cell phenotype and function and the cells attempted to phagocytize these spiky elevations in vitro. Therefore, micro-structured implants used in dental surgery should avoid any spiky topography on their surface. The sandblasted, acid-etched, and heat-treated yttria-stabilized zirconia (cer.face®14) surface was characterized by scanning electron microscopy and energy dispersive X-ray. In vitro studies with human MG-63 osteoblasts focused on cell attachment and intracellular stress level. The cer.face 14 surface featured a landscape with nano-micro hills that was most sinusoidal-shaped. The mildly curved profile proved to be a suitable material for cell anchorage. MG-63 cells on cer.face 14 showed a very low reactive oxygen species (ROS) generation similar to that on the extracellular matrix protein collagen I (Col). Intracellular adenosine triphosphate (ATP) levels were comparable to Col. Ceramic cer.face 14, with its sinusoidal-shaped surface structure, facilitates cell anchorage and prevents cell stress. View Full-Text
Keywords: dental ceramic implant; zirconia; nano-micro topography; EDX; scanning electron microscopy; osteoblasts; cell anchorage; in vitro; ROS; ATP dental ceramic implant; zirconia; nano-micro topography; EDX; scanning electron microscopy; osteoblasts; cell anchorage; in vitro; ROS; ATP
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MDPI and ACS Style

Staehlke, S.; Springer, A.; Freitag, T.; Brief, J.; Nebe, J.B. The Anchorage of Bone Cells onto an Yttria-Stabilized Zirconia Surface with Mild Nano-Micro Curved Profiles. Dent. J. 2020, 8, 127. https://doi.org/10.3390/dj8040127

AMA Style

Staehlke S, Springer A, Freitag T, Brief J, Nebe JB. The Anchorage of Bone Cells onto an Yttria-Stabilized Zirconia Surface with Mild Nano-Micro Curved Profiles. Dentistry Journal. 2020; 8(4):127. https://doi.org/10.3390/dj8040127

Chicago/Turabian Style

Staehlke, Susanne, Armin Springer, Thomas Freitag, Jakob Brief, and J. B. Nebe 2020. "The Anchorage of Bone Cells onto an Yttria-Stabilized Zirconia Surface with Mild Nano-Micro Curved Profiles" Dentistry Journal 8, no. 4: 127. https://doi.org/10.3390/dj8040127

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