Effect of a Recombinant Human Basic Fibroblast Growth Factor 2 (rhFGF-2)-Impregnated Atelocollagen Sponge on Vertical Guided Bone Regeneration in a Rat Calvarial Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Preparation of FGF-2 Incorporated in the Atelocollagen Sponge
2.3. Surgical Procedures
2.4. Micro-Computed Tomography Imaging
2.5. Histological and Histomorphometric Analyses
2.6. Statistical Analyses
3. Results
3.1. Micro-CT Images
3.2. Histological Observation and Histomorphometric Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
FGF-2 | fibroblast growth factor 2 |
Micro-CT | micro-computed tomography |
BV | bone volume |
GBR | guided bone regeneration |
rhFGF-2 | recombinant human fibroblast growth factor 2 |
β-TCP | β-tricalcium phosphate |
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Area of Newly Augmented Bone (%) | Height of Newly Augmented Bone (%) | |||
---|---|---|---|---|
0.3% rhFGF-2 | 35.6 | (9.7) | 41.9 | (6.7) |
Control | 9.1 | (3.2) | 13.4 | (7.3) |
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Kogure, K.; Hasuike, A.; Kurachi, R.; Igarashi, Y.; Idesawa, M.; Sato, S. Effect of a Recombinant Human Basic Fibroblast Growth Factor 2 (rhFGF-2)-Impregnated Atelocollagen Sponge on Vertical Guided Bone Regeneration in a Rat Calvarial Model. Dent. J. 2025, 13, 177. https://doi.org/10.3390/dj13040177
Kogure K, Hasuike A, Kurachi R, Igarashi Y, Idesawa M, Sato S. Effect of a Recombinant Human Basic Fibroblast Growth Factor 2 (rhFGF-2)-Impregnated Atelocollagen Sponge on Vertical Guided Bone Regeneration in a Rat Calvarial Model. Dentistry Journal. 2025; 13(4):177. https://doi.org/10.3390/dj13040177
Chicago/Turabian StyleKogure, Keisuke, Akira Hasuike, Risa Kurachi, Yasuyuki Igarashi, Masataka Idesawa, and Shuichi Sato. 2025. "Effect of a Recombinant Human Basic Fibroblast Growth Factor 2 (rhFGF-2)-Impregnated Atelocollagen Sponge on Vertical Guided Bone Regeneration in a Rat Calvarial Model" Dentistry Journal 13, no. 4: 177. https://doi.org/10.3390/dj13040177
APA StyleKogure, K., Hasuike, A., Kurachi, R., Igarashi, Y., Idesawa, M., & Sato, S. (2025). Effect of a Recombinant Human Basic Fibroblast Growth Factor 2 (rhFGF-2)-Impregnated Atelocollagen Sponge on Vertical Guided Bone Regeneration in a Rat Calvarial Model. Dentistry Journal, 13(4), 177. https://doi.org/10.3390/dj13040177