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Photonics 2018, 5(1), 5;

Design Considerations for Integration of Terahertz Time-Domain Spectroscopy in Microfluidic Platforms

School of Engineering, University of Guelph, Guelph, ON N1G 2W1, Canada
Author to whom correspondence should be addressed.
Received: 4 February 2018 / Revised: 6 March 2018 / Accepted: 9 March 2018 / Published: 10 March 2018
(This article belongs to the Special Issue Microwave Photonics 2017)
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Microfluidic platforms have received much attention in recent years. In particular, there is interest in combining spectroscopy with microfluidic platforms. This work investigates the integration of microfluidic platforms and terahertz time-domain spectroscopy (THz-TDS) systems. A semiclassical computational model is used to simulate the emission of THz radiation from a GaAs photoconductive THz emitter. This model incorporates white noise with increasing noise amplitude (corresponding to decreasing dynamic range values). White noise is selected over other noise due to its contributions in THz-TDS systems. The results from this semiclassical computational model, in combination with defined sample thicknesses, can provide the maximum measurable absorption coefficient for a microfluidic-based THz-TDS system. The maximum measurable frequencies for such systems can be extracted through the relationship between the maximum measurable absorption coefficient and the absorption coefficient for representative biofluids. The sample thickness of the microfluidic platform and the dynamic range of the THz-TDS system play a role in defining the maximum measurable frequency for microfluidic-based THz-TDS systems. The results of this work serve as a design tool for the development of such systems. View Full-Text
Keywords: terahertz; biomedical optics; microfluidics; spectroscopy terahertz; biomedical optics; microfluidics; spectroscopy

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Al-Hujazy, R.; Collier, C.M. Design Considerations for Integration of Terahertz Time-Domain Spectroscopy in Microfluidic Platforms. Photonics 2018, 5, 5.

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