Next Article in Journal
Extraction by Subcritical and Supercritical Water, Methanol, Ethanol and Their Mixtures
Previous Article in Journal
Advances and Pitfalls in the Capillary Electrophoresis Analysis of Aggregates of Beta Amyloid Peptides
Open AccessArticle

Chiral Recognition by DNA-Immobilized TLC Plate

Department of Chemistry, Faculty of Science, Okayama University of Science, Ridaicho 1-1, Kita-ku, Okayama 700-0005, Japan
*
Author to whom correspondence should be addressed.
Separations 2018, 5(1), 3; https://doi.org/10.3390/separations5010003
Received: 8 November 2017 / Revised: 20 December 2017 / Accepted: 22 December 2017 / Published: 26 December 2017
DNA-immobilized silica gel TLC plate (DNA-TLC plate) by coating a mixture of double-stranded DNA and silica gel on a glass plate was stable in common organic solvents, such as alcohol, acetone, chloroform, and ethyl acetate. DNA-TLC plate showed different Rf values for the L- and D-form acidic amino acids, such as aspartic acid and glutamic acid. The chiral recognition of an acidic amino acid by the DNA-TLC was related to the interaction between the nucleic acid base, particularly guanine (G) and cytosine (C), and the amino acid. Furthermore, the DNA-TLC plate indicated the recognition of a chiral metal complex, such as the tris(1,10-phenanthroline)ruthenium(II) ([Ru(phen)3]2+) salt, which has Λ- and Δ-forms. Therefore, the double-stranded DNA-TLC plate may have the potential to be utilized as a chiral separation material for amino acids, peptides, and a metal complex with a chiral property. View Full-Text
Keywords: chiral recognition; DNA; amino acid; metal complex; thin layer chromatography; organic-inorganic hybrid material chiral recognition; DNA; amino acid; metal complex; thin layer chromatography; organic-inorganic hybrid material
Show Figures

Figure 1

MDPI and ACS Style

Yamada, M.; Inoue, M. Chiral Recognition by DNA-Immobilized TLC Plate. Separations 2018, 5, 3.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop