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Dermatopathology
Volume 12
Issue 2
10.3390/dermatopathology12020015
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Clinicopathological Challenge

Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge

by
Jason El Jalkh
1,
Pia Maria Obeid
1,
Dorra Guermazi
2,
Aya Soubra
3 and
Elie Saliba
1,*
1
Department of Dermatology, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut 13-5053, Lebanon
2
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
3
Department of Pathology, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut 13-5053, Lebanon
*
Author to whom correspondence should be addressed.
Dermatopathology 2025, 12(2), 15; https://doi.org/10.3390/dermatopathology12020015
Submission received: 7 December 2024 / Revised: 12 May 2025 / Accepted: 13 May 2025 / Published: 14 May 2025
(This article belongs to the Section Clinico-Pathological Correlation in Dermatopathology)
Versions Notes

Abstract

A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and topical calcineurin inhibitor. Histopathologic examination showed a regular epidermis with increased melanophages in the papillary dermis, without vacuolar degeneration of the basement membrane. Verhoeff Van Gieson stain highlighted a band-like zone of attenuated elastic fibers in the papillary dermis, while Von Kossa stain was negative for calcified fibers. PAS staining was negative for fungal organisms and Alcian blue showed no increase in dermal mucin.
Keywords: pseudoxanthoma elasticum-like papillary dermal elastolysis; acquired elastic tissue disorder; trifarotene therapy; histopathology; dermatopathology pseudoxanthoma elasticum-like papillary dermal elastolysis; acquired elastic tissue disorder; trifarotene therapy; histopathology; dermatopathology

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MDPI and ACS Style

El Jalkh, J.; Obeid, P.M.; Guermazi, D.; Soubra, A.; Saliba, E. Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge. Dermatopathology 2025, 12, 15. https://doi.org/10.3390/dermatopathology12020015

AMA Style

El Jalkh J, Obeid PM, Guermazi D, Soubra A, Saliba E. Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge. Dermatopathology. 2025; 12(2):15. https://doi.org/10.3390/dermatopathology12020015

Chicago/Turabian Style

El Jalkh, Jason, Pia Maria Obeid, Dorra Guermazi, Aya Soubra, and Elie Saliba. 2025. "Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge" Dermatopathology 12, no. 2: 15. https://doi.org/10.3390/dermatopathology12020015

APA Style

El Jalkh, J., Obeid, P. M., Guermazi, D., Soubra, A., & Saliba, E. (2025). Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge. Dermatopathology, 12(2), 15. https://doi.org/10.3390/dermatopathology12020015

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