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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..

GERMS, Volume 3, Issue 3 (09 2013) – 4 articles

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339 KB  
Case Report
Permanent Pacemaker-Associated actinomycetemcomitans Endocarditis: A Case Report
by Zhenhong Li, Jennifer Madeo, Shadab Ahmed, Alex Vidal, Amgad Makaryus, Jose Mejia and Tabassum Yasmin
GERMS 2013, 3(3), 96-101; https://doi.org/10.11599/germs.2013.1043 - 1 Sep 2013
Cited by 4 | Viewed by 9
Abstract
Aggregatibacter actinomycetemcomitans is a Gram-negative bacillus, member of the HACEK group of bacteria, and it is a very rare cause of endocarditis. It is also an extremely rare cause of device-associated infection of the heart. We describe the case of a 25 year-old [...] Read more.
Aggregatibacter actinomycetemcomitans is a Gram-negative bacillus, member of the HACEK group of bacteria, and it is a very rare cause of endocarditis. It is also an extremely rare cause of device-associated infection of the heart. We describe the case of a 25 year-old man who presented with pacemaker-associated endocarditis due to Aggregatibacter actinomycetemcomitans and also discuss the implications and treatment of this organism. Full article
392 KB  
Article
Nine-Year Follow-Up of HIV-Infected Romanian Children and Adolescents Receiving Lopinavir/Ritonavir-Containing Highly Active Antiretroviral Therapy
by Richard S. B. Wanless, Sorin Rugină, Simona Maria Ruță, Irina-Magdalena Dumitru, Roxana Carmen Cernat, Heidi L. Schwarzwald, Nancy R. Calles, Gordon E. Schutze, Ana-Maria Schweitzer, Heather R. Draper and Mark W. Kline
GERMS 2013, 3(3), 90-95; https://doi.org/10.11599/germs.2013.1042 - 1 Sep 2013
Cited by 6 | Viewed by 9
Abstract
Introduction: Many Romanian children were infected nosocomially with human immunodeficiency virus (HIV) in the late 1980s. The Romanian-American Children's Center of Excellence in Constanţa continues to follow approximately 450 of these patients. In 2001, 414 of these patients were initiated on triple therapy [...] Read more.
Introduction: Many Romanian children were infected nosocomially with human immunodeficiency virus (HIV) in the late 1980s. The Romanian-American Children's Center of Excellence in Constanţa continues to follow approximately 450 of these patients. In 2001, 414 of these patients were initiated on triple therapy including lopinavir/ritonavir. Data from this cohort treated through August 2006 were published in April 2007 demonstrating that the treatment was well tolerated, with 337 children (81%) remaining on therapy after a median duration of >4 years. The current article describes the results of continued analysis of this cohort through end 2010. The objective of the study was to determine the long-term clinical outcomes of children and adolescents commenced on antiretroviral therapy (ART) including lopinavir/ritonavir. Methods: Data were extracted retrospectively from the charts of the 336 patients remaining on lopinavir/ritonavir in August 2006. The following outcomes were analyzed: mortality, current patient status, viral load (VL), CD4 counts and reasons for discontinuation of lopinavir/ritonavir. Results: The median age at initiation of lopinavir/ritonavir was 14.0 years (range 5.4 to 20.0 years). The median time on lopinavir/ritonavir treatment was 7.5 years (interquartile range 5.7 to 8.6 years). Overall mortality was 13.5%. Of the original 414 patients started on lopinavir/ritonavir in 2001, 199 (48.1%) remained on this therapy at the end of 2010 and of these 63.8% had undetectable viral load. Conclusions: Despite initial suboptimal ART, a significant proportion of patients subsequently treated with a lopinavir/ritonavir based regimen remained on this therapy for up to nine years. Full article
423 KB  
Article
The Role of Rotavirus Associated with Pediatric Gastroenteritis in a General Hospital in Lagos, Nigeria
by Philip Ifesinachi Anochie, Edwina Chinwe Onyeneke, Emmanuel Osaretin Asowata, Ebelechukwu Afocha, Anthony Chidiebere Onyeozirila, Angelina Chinyere Ogu and Bestman Chukwuemeka Onyeneke
GERMS 2013, 3(3), 81-89; https://doi.org/10.11599/germs.2013.1041 - 1 Sep 2013
Cited by 3 | Viewed by 15
Abstract
Introduction: Bacterial, viral and parasitic agents have been implicated and confirmed as causative agents of gastroenteritis in children with ages below 5 years old. The major role of rotavirus as causative agent is not widely recognized within the public health community, particularly in [...] Read more.
Introduction: Bacterial, viral and parasitic agents have been implicated and confirmed as causative agents of gastroenteritis in children with ages below 5 years old. The major role of rotavirus as causative agent is not widely recognized within the public health community, particularly in developing countries. This study examined the role of rotavirus as a causative agent of childhood gastroenteritis in infants and young children below 5 years of age in a General Hospital in Lagos, Nigeria. Methods: Parents and caregivers of children admitted to the hospital were interviewed using a structured questionnaire. Viral RNA was extracted from the stool samples collected and analyzed using RT-PCR for genotyping and agarose gel electrophoresis for identification of rotavirus electrophoretypes. Results: Out of the 71 samples analyzed, 16 (22.5%) were positive for rotavirus. A total of 12 (75%) males and 4 (25%) females were positive for rotavirus gastroenteritis with most cases (7, 43.8%) distributed to the 13–24 months age group, followed closely by the 1–6 months age group, with 6 cases, 37.5%. Rotavirus G2 genotype was the most prevalent strain in the hospital (10 patients, 62.5%) followed by G1 (6 patients, 37.5%). These were the only rotavirus genotypes detected in the hospital. Full article
99 KB  
Editorial
At the End of Summer
by Anca Streinu-Cercel
GERMS 2013, 3(3), 80; https://doi.org/10.11599/germs.2013.1040 - 1 Sep 2013
Cited by 1 | Viewed by 12
Abstract
As the summer holiday comes to an end, so does the travel quest throughout the world, and with it the baggage of GERMS that we have come in contact with.[...] Full article
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