Microfluidic Network Simulations Enable On-Demand Prediction of Control Parameters for Operating Lab-on-a-Chip-Devices
Round 1
Reviewer 1 Report
The authors present a simulator for modeling a microfluidic network. They validated the simulator performance for in-line prediction and operation of flow and pressure characteristics on a microfluidic apparatus for creating laminar flows and forming droplets. The paper deserves to be published.
The authors should check references and remove symbols “[REF]” on p. 1, “[Kirchhoff1845]” on p. 4, “TO DO: Describe final data analysis work flows” on p. 17, and “Data Availability Statement” on p. 18.
Author Response
Thank you very much for the encouragement and remarks. The manuscript has gone under full revision and all reported remarks have been implemented and fixed.
Reviewer 2 Report
In this paper, a microfluidic network capable of accurately controlling liquid pressure was designed, and the proof-of-concept experiments for the proposed MFNsolver for pressure-driven were presented microfluidics at specific flow rates, which is innovative. I still have a few questions that need to be explained by the author. After these questions are answered, I think this paper can be accepted. 1. Which areas can this MFN designed in this paper be applied？ 2. In Figure 9, what is the size of the resulting droplet? How homogeneous is it? 3. The microfluidic chip is prepared by photolithography and wet-etching, how long it takes to manufacture such a chip, and whether this method is still applicable if more complex structures are to be designed and fabricated？Author Response
Thank you very much for the remarks. The manuscript has gone under full revision and all suggestions to the content of the manuscript have been implemented.
Author Response File: 
Author Response.pdf
