Influence of Process Design on the Preparation of Solid Lipid Nanoparticles by an Ultrasonic-Nanoemulsification Method
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Solid Lipid Nanoparticles
2.3. Characterization Methods
2.3.1. Particle Size and Polydispersity Index by Dynamic Light Scattering
2.3.2. Surface Charge by Electrophoretic Light Scattering
2.3.3. Morphological Characterization by Atomic Force Microscopy and Transmission Electron Microscopy
2.3.4. Kinetic Stability by Multiple Light Scattering
2.3.5. Thermal Analysis by Differential Scanning Calorimetry
3. Results and Discussion
4. Conclusions
Funding
Data Availability Statement
Conflicts of Interest
References
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System Number | Ultrasonication Time (min) | Amplitude (%) | Number of Cycles |
---|---|---|---|
1 | 3 | 100 | 1 |
2 | 3 | 100 | 0.5 |
3 | 3 | 75 | 1 |
4 | 3 | 75 | 0.5 |
5 | 3 | 50 | 1 |
6 | 3 | 50 | 0.5 |
7 | 5 | 100 | 1 |
8 | 5 | 100 | 0.5 |
9 | 5 | 75 | 1 |
10 | 5 | 75 | 0.5 |
11 | 5 | 50 | 1 |
12 | 5 | 50 | 0.5 |
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Pucek-Kaczmarek, A. Influence of Process Design on the Preparation of Solid Lipid Nanoparticles by an Ultrasonic-Nanoemulsification Method. Processes 2021, 9, 1265. https://doi.org/10.3390/pr9081265
Pucek-Kaczmarek A. Influence of Process Design on the Preparation of Solid Lipid Nanoparticles by an Ultrasonic-Nanoemulsification Method. Processes. 2021; 9(8):1265. https://doi.org/10.3390/pr9081265
Chicago/Turabian StylePucek-Kaczmarek, Agata. 2021. "Influence of Process Design on the Preparation of Solid Lipid Nanoparticles by an Ultrasonic-Nanoemulsification Method" Processes 9, no. 8: 1265. https://doi.org/10.3390/pr9081265