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Open AccessReview

The Significance of Natural Product Derivatives and Traditional Medicine for COVID-19

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The Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Fei Shan Jie 32, Guiyang 550003, China
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Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1280 Main St. W., Hamilton, ON L8N 3Z5, Canada
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Department of Medicine, Vanderbilt University Medical Center, 318 Preston Research Building, 2200 Pierce Avenue, Nashville, TN 37232, USA
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Oral and Maxillofacial Radiology, Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
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Department of Biochemical Pharmacology and Drug Design, Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences, 21 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria
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Department of Biotechnology and Nutrigenomics, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
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Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
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Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University Vienna, Waehringer Guertel 18–20, 1090 Vienna, Austria
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Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland
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Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
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Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria
*
Authors to whom correspondence should be addressed.
Processes 2020, 8(8), 937; https://doi.org/10.3390/pr8080937
Received: 3 July 2020 / Revised: 30 July 2020 / Accepted: 30 July 2020 / Published: 4 August 2020
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, there have been more than 10 million reported cases, more than 517,000 deaths in 215 countries, areas or territories. There is no effective antiviral medicine to prevent or treat COVID-19. Natural products and traditional medicine products with known safety profiles are a promising source for the discovery of new drug leads. There is increasing number of publications reporting the effect of natural products and traditional medicine products on COVID-19. In our review, we provide an overview of natural products and their derivatives or mimics, as well as traditional medicine products, which were reported to exhibit potential to inhibit SARS-CoV-2 infection in vitro, and to manage COVID-19 in vivo, or in clinical reports or trials. These natural products and traditional medicine products are categorized in several classes: (1) anti-malaria drugs including chloroquine and hydroxychloroquine, (2) antivirals including nucleoside analogs (remdesivir, favipiravir, β-D-N4-hydroxycytidine, ribavirin and among others), lopinavir/ritonavir and arbidol, (3) antibiotics including azithromycin, ivermectin and teicoplanin, (4) anti-protozoal drug, emetine, anti-cancer drug, homoharringtonine, and others, as well as (5) traditional medicine (Lian Hua Qing Wen Capsule, Shuang Huang Lian Oral Liquid, Qingfei Paidu Decoction and Scutellariae Radix). Randomized, double-blind and placebo-controlled large clinical trials are needed to provide solid evidence for the potential effective treatment. Currently, drug repurposing is a promising strategy to quickly find an effective treatment for COVID-19. In addition, carefully combined cocktails need to be examined for preventing a COVID-19 pandemic and the resulting global health concerns. View Full-Text
Keywords: SARS-CoV; coronavirus; traditional Chinese medicine; COVID-19; natural products SARS-CoV; coronavirus; traditional Chinese medicine; COVID-19; natural products
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Figure 1

MDPI and ACS Style

Wang, D.; Huang, J.; Yeung, A.W.K.; Tzvetkov, N.T.; Horbańczuk, J.O.; Willschke, H.; Gai, Z.; Atanasov, A.G. The Significance of Natural Product Derivatives and Traditional Medicine for COVID-19. Processes 2020, 8, 937.

AMA Style

Wang D, Huang J, Yeung AWK, Tzvetkov NT, Horbańczuk JO, Willschke H, Gai Z, Atanasov AG. The Significance of Natural Product Derivatives and Traditional Medicine for COVID-19. Processes. 2020; 8(8):937.

Chicago/Turabian Style

Wang, Dongdong; Huang, Jiansheng; Yeung, Andy W.K.; Tzvetkov, Nikolay T.; Horbańczuk, Jarosław O.; Willschke, Harald; Gai, Zhibo; Atanasov, Atanas G. 2020. "The Significance of Natural Product Derivatives and Traditional Medicine for COVID-19" Processes 8, no. 8: 937.

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