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Open AccessFeature PaperArticle

Kaempferol Rhamnosides from Geranium sibiricum as Aldose Reductase Inhibitors and Their Content by HPLC Analysis

1
Department of Plant Science and Technology, Chung-Ang University, Anseong 17546, Korea
2
Division of Forest Biodiversity, Korea National Arboretum, Pocheon 11186, Korea
3
Department of Food and Nutrition, Chung-Ang University, Anseong 17546, Korea
*
Author to whom correspondence should be addressed.
Processes 2020, 8(6), 694; https://doi.org/10.3390/pr8060694
Received: 8 May 2020 / Revised: 10 June 2020 / Accepted: 11 June 2020 / Published: 15 June 2020
(This article belongs to the Special Issue Metabolic Analysis in Food Processing)
The study aimed to assess the aldose reductase (AR) inhibition of selected Geranium species and determine the bioactive flavonoid constituents. Flavonoids are known to be good AR inhibitors. Among the species examined, G. sibiricum exhibited potent inhibition of AR (IC50 value, 2.4 µg/mL). Further examination of G. sibiricum, after solvent extraction and fractionation, revealed that the ethyl acetate fraction (IC50 value, 0.41 µg/mL) had a potent AR inhibitory effect. Kaempferol rhamnosides were the active compounds from this fraction. Moreover, G. sibiricum showed the highest content of kaempferol-7-O-rhamnoside and kaempferol-3,7-O-dirhamnoside among the samples examined with a concentration in the extracts of 28.1 and 2.2 mg/g, respectively. This study shows that G. sibiricum exhibits promising AR inhibitory activity, which can be explored further as a natural therapy for treating and managing complications associated with diabetes. View Full-Text
Keywords: Geranium sibiricum; aldose reductase; HPLC-UV; flavonoid rhamnoside Geranium sibiricum; aldose reductase; HPLC-UV; flavonoid rhamnoside
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MDPI and ACS Style

Quilantang, N.G.; Choi, K.; Lee, B.-H.; Lee, S. Kaempferol Rhamnosides from Geranium sibiricum as Aldose Reductase Inhibitors and Their Content by HPLC Analysis. Processes 2020, 8, 694.

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