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Open AccessArticle

Antidiabetic and Antilipidemic Activity of Root Extracts of Salacia oblonga against Streptozotocin-Induced Diabetes in Wistar Rats

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Department of Biochemistry & Bioinformatics, Institute of Science and GITAM (Deemed to be University); Visakhapatnam, Andhra Pradesh 530045, India
2
GITAM Institute of Pharmacy, GITAM (Deemed to be University) Visakhapatnam 530 045, Andhra Pradesh, India
3
Plant Production Department, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
4
Precision Agriculture Laboratory, Department of Pomology, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21544, Egypt
*
Author to whom correspondence should be addressed.
Processes 2020, 8(3), 301; https://doi.org/10.3390/pr8030301
Received: 3 February 2020 / Revised: 25 February 2020 / Accepted: 28 February 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Extraction, Characterization and Pharmacology of Natural Products)
Salacia oblonga is used to treat diabetes, hypocholesteremia, gonorrhea, rheumatism, asthma, inflammation, oxidative stress, etc. In the present study, the antidiabetic activity of S. oblonga methanolic root extracts collected from three geographical locations, viz., Eleshwaram (Andhra Pradesh), Thoothukudi (Tamil Nadu), and Karwar (Karnataka), was studied in vitro. Among the three extracts, S. oblonga root extracts from Eleshwaram showed maximum α-glucosidase and α-amylase inhibitory activities, indicating better antidiabetic activity. Acute toxicity studies of S. oblonga carried out in Albino Wistar rats showed no toxicity. Further, in vivo studies showed antidiabetic and antilipidemic activities in Albino Wistar rats with induced type II diabetes mellitus. Type II diabetes mellitus was induced in the experimental rats by intraperitoneal injection of nicotinamide and streptozotocin. The rats were orally fed different doses (ranging from 0 to 400 mg/kg body weight) of S. oblonga root extracts from Eleshwaram for 14 days. Blood glucose, lipid, bilirubin, and creatinine levels were analyzed on day 0, 7, and 14. The S. oblonga root extract from Eleshwaram decreased the glucose levels in a dose-dependent manner as well as the lipid, creatinine, and bilirubin levels in diabetic rats. Thus, the present study demonstrates antidiabetic and antilipidemic properties of S. oblonga root extracts. View Full-Text
Keywords: antidiabetic; antilipidemic; acarbose; α-glucosidase inhibitors; diabetes mellitus; Salacia oblonga antidiabetic; antilipidemic; acarbose; α-glucosidase inhibitors; diabetes mellitus; Salacia oblonga
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Deepak, K.G.K.; Challa, S.; Suhasin, G.; Nagesewara Rao Reddy, N.; Elansary, H.O.; El-Ansary, D.O. Antidiabetic and Antilipidemic Activity of Root Extracts of Salacia oblonga against Streptozotocin-Induced Diabetes in Wistar Rats. Processes 2020, 8, 301.

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