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Open AccessFeature PaperReview

Liquid Biphasic System: A Recent Bioseparation Technology

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Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih 43500, Malaysia
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College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
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School of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, Semenyih 43500, Malaysia
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Department of Fundamental and Applied Sciences, Centre for Biofuel and Biochemical Research, Institute of Self-Sustainable Building, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Malaysia
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Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
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Taipei Economic and Cultural Office, Prague, Czech Republic, Evropská 33C, 160 00 Praha 6, Czechia
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Department of Chemical and Material Engineering, Tunghai University, Taiwan 407
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Authors to whom correspondence should be addressed.
Processes 2020, 8(2), 149; https://doi.org/10.3390/pr8020149
Received: 16 December 2019 / Revised: 16 January 2020 / Accepted: 17 January 2020 / Published: 23 January 2020
(This article belongs to the Special Issue Green Technologies: Bridging Conventional Practices and Industry 4.0)
A well-known bioseparation technique namely liquid biphasic system (LBS) has attracted many researchers’ interest for being an alternative bioseparation technology for various kinds of biomolecules. The present review begins with an in-depth discussion on the fundamental principle of LBS and this is followed by the discussion on further development of various phase-forming components in LBS. Additionally, the implementation of various advance technologies to the LBS that is beneficial towards the efficiency of LBS for the extraction, separation, and purification of biomolecules was discussed. The key parameters affecting the LBS were presented and evaluated. Moreover, future prospect and challenges were highlighted to be a useful guide for future development of LBS. The efforts presented in this review will provide an insight for future researches in liquid-liquid separation techniques. View Full-Text
Keywords: liquid biphasic system; aqueous two-phase system; aqueous biphasic system; purification; separation; recovery; biomolecules liquid biphasic system; aqueous two-phase system; aqueous biphasic system; purification; separation; recovery; biomolecules
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MDPI and ACS Style

Khoo, K.S.; Leong, H.Y.; Chew, K.W.; Lim, J.-W.; Ling, T.C.; Show, P.L.; Yen, H.-W. Liquid Biphasic System: A Recent Bioseparation Technology. Processes 2020, 8, 149.

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