An Overview of Exosomes in Cancer Therapy: A Small Solution to a Big Problem
Round 1
Reviewer 1 Report
In tis review article, authors summarize the characteristics and composition of exosomes. Further, they discuss therapeutic application of exosomes alonwith considerations about exosome application in immunotherapy. Exosome isolation and loading methods are summarized as well. Overall, it is a comprehensive review article with appropriate figures and tables. However, the review can be improved by addressing following point:
Clinical trials summarized in Table 2 should be elaborated in the article.
Author Response
Manuscript ID: processes-993421
Type of manuscript: Review
Title: An Overview of Exosomes in Cancer Therapy: A Small Solution to a Big Problem
Authors: Paulo Rodrigues, Catarina Melim, Francisco Veiga, Ana Figueiras *
Mr. Aleksandar Jovanović, B.Sc.
Assistant Editor, MDPI AG
The authors appreciate the careful review and greatly acknowledge the comments that the Reviewers have provided on our manuscript. We have carefully revised the manuscript and have made the recommended changes and answered in detail to the questions raised. Additional information was also added when appropriate. All changes made to the text are highlighted in yellow colour. Please find below a point-by-point list of answers to the reviewers’ concerns.
#Reviewer 1:
Comments and Suggestions for Authors
In this review article, authors summarize the characteristics and composition of exosomes. Further, they discuss therapeutic application of exosomes alon with considerations about exosome application in immunotherapy. Exosome isolation and loading methods are summarized as well. Overall, it is a comprehensive review article with appropriate figures and tables. However, the review can be improved by addressing following point:
Clinical trials summarized in Table 2 should be elaborated in the article.
Response:
The authors thank the reviewer’s suggestion. Some paragraphs were added in order to elaborate clinical trials. Please see lines 670 to 677.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript by Netti, Lucarelli et al describes the potential role of Ptx3 in the pathogenesis of renal carcinoma and as tumor marker.
I would like to congratulate with the authors because the study design is linear and the data well-presented. Moreover, conclusions are well supported by the results.
It could be interesting to cite and discuss this very recently paper:
Recent Advances in Extracellular Vesicles as Drug Delivery Systems and Their Potential in Precision Medicine. Pharmaceutics. 2020 Oct 22;12(11):E1006. doi: 10.3390/pharmaceutics12111006.
Extracellular Vesicles as Biomarkers in Cancer Immunotherapy. Cancers (Basel). 2020 Sep 30;12(10):E2825. doi: 10.3390/cancers12102825.Author Response
Manuscript ID: processes-993421
Type of manuscript: Review
Title: An Overview of Exosomes in Cancer Therapy: A Small Solution to a Big Problem
Authors: Paulo Rodrigues, Catarina Melim, Francisco Veiga, Ana Figueiras *
Mr. Aleksandar Jovanović, B.Sc.
Assistant Editor, MDPI AG
The authors appreciate the careful review and greatly acknowledge the comments that the Reviewers have provided on our manuscript. We have carefully revised the manuscript and have made the recommended changes and answered in detail to the questions raised. Additional information was also added when appropriate. All changes made to the text are highlighted in yellow colour. Please find below a point-by-point list of answers to the reviewers’ concerns.
#Reviewer 2:
The manuscript by Netti, Lucarelli et al describes the potential role of Ptx3 in the pathogenesis of renal carcinoma and as tumor marker.
I would like to congratulate with the authors because the study design is linear and the data well-presented. Moreover, conclusions are well supported by the results.
It could be interesting to cite and discuss this very recently paper:
Recent Advances in Extracellular Vesicles as Drug Delivery Systems and Their Potential in Precision Medicine. de Jong B, Barros ER, Hoenderop JGJ, Rigalli JP. Pharmaceutics. 2020 Oct 22;12(11):E1006. doi: 10.3390/pharmaceutics12111006.
Extracellular Vesicles as Biomarkers in Cancer Immunotherapy. Mathew M, Zade M, Mezghani N, Patel R, Wang Y, Momen-Heravi F. Cancers (Basel). 2020 Sep 30;12(10):E2825. doi: 10.3390/cancers12102825.
Response:
The authors thank the reviewer’s suggestion. Some paragraphs were added in order to discuss the mentioned articles. (Please see lines 268 to 271 and lines 371 to 321).
Author Response File: Author Response.pdf
