Next Article in Journal
Hygro-Thermo-Mechanical Responses of Balsa Wood Core Sandwich Composite Beam Exposed to Fire
Previous Article in Journal
Preparation of Sawdust-Filled Recycled-PET Composites via Solid-State Compounding
Previous Article in Special Issue
Baicalein-Enriched Fraction Extracted from Oroxylum indicum (L.) Benth. ex Kurz Leaves Exerts Antioxidant and Inhibitory Effects Against Glioblastoma Multiforme
Open AccessFeature PaperArticle

The Effects of Lung-Moistening Herbal Medicines on Bleomycin-Induced Pulmonary Fibrosis Mouse Model

1
College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
2
College of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea
3
Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally as first author.
Processes 2020, 8(1), 102; https://doi.org/10.3390/pr8010102
Received: 5 November 2019 / Revised: 8 January 2020 / Accepted: 9 January 2020 / Published: 12 January 2020
(This article belongs to the Special Issue Cancer Systems Biology and Natural Products)
In traditional medicine, lung-moistening herbal medicines (LMHM) are regarded as a major option for treating symptoms of pulmonary fibrosis (PF) including dry cough and dyspnea. As PF agents are being applied to the development of lung cancer agents, PF and lung cancer are reported to have high pathological and pharmacological relationships. This study was proposed to identify candidates for the treatment of PF via investigating the effect of LMHM on PF mouse model. PF was induced by intratracheal instillation of bleomycin. Six water extracts of LMHM such as Farfarae Flos (FAF), Trichosanthis Semen (TRS), Lilii Bulbus (LIB), Adenophorae Radix (ADR), Asteris Radix (ASR), and Scrophulariae Radix (SCR) were prepared and administered (300 mg/kg) orally for 10 days after induction. The changes in body weight, histopathology, and immune cell of bronchoalveolar lavage fluid (BALF) were investigated. Among those, LIB and ADR significantly decreased the deposition of collagen and septal thickness of alveolar and terminal bronchiole. Moreover, SCR, TRS, LIB, and ADR decreased total cells, macrophages, and lymphocytes in BALF. Taken together, ADR and LIB could be the candidates to reduce PF. Further studies on their effects at different doses and analysis of their underlying molecular mechanisms are needed. View Full-Text
Keywords: pulmonary fibrosis; bleomycin; herbal medicine; broncho alveolar lavage fluid; inflammation pulmonary fibrosis; bleomycin; herbal medicine; broncho alveolar lavage fluid; inflammation
Show Figures

Graphical abstract

MDPI and ACS Style

Ahn, J.; Joo, H.; Park, J.; Park, J.-W.; Kim, K.-I.; Jung, H.-J.; Bu, Y.; Lee, B.-J. The Effects of Lung-Moistening Herbal Medicines on Bleomycin-Induced Pulmonary Fibrosis Mouse Model. Processes 2020, 8, 102.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop