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Open AccessArticle

Development of Hydrophilic Drug Encapsulation and Controlled Release Using a Modified Nanoprecipitation Method

1
College of Biotechnology and Sericultural Research Institute, Jiangsu University of Science and Technology, Zhenjiang 212018, China
2
Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
3
Institute of Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou 215123, China
*
Author to whom correspondence should be addressed.
Processes 2019, 7(6), 331; https://doi.org/10.3390/pr7060331
Received: 28 March 2019 / Revised: 7 May 2019 / Accepted: 16 May 2019 / Published: 1 June 2019
(This article belongs to the Special Issue Synthesis and Characterization of Biomedical Materials)
The improvement of the loading content of hydrophilic drugs by polymer nanoparticles (NPs) recently has received increased attention from the field of controlled release. We developed a novel, simply modified, drop-wise nanoprecipitation method which separated hydrophilic drugs and polymers into aqueous phase (continuous phase) and organic phase (dispersed phase), both individually and involving a mixing process. Using this method, we produced ciprofloxacin-loaded NPs by Poly (d,l-lactic acid)-Dextran (PLA-DEX) and Poly lactic acid-co-glycolic acid-Polyethylene glycol (PLGA-PEG) successfully, with a considerable drug-loading ability up to 27.2 wt% and an in vitro sustained release for up to six days. Drug content with NPs can be precisely tuned by changing the initial drug feed concentration of ciprofloxacin. These studies suggest that this modified nanoprecipitation method is a rapid, facile, and reproducible technique for making nano-scale drug delivery carriers with high drug-loading abilities View Full-Text
Keywords: diblock copolymers; drug delivery systems; nanoparticles; nanoprecipitation; self-assembly diblock copolymers; drug delivery systems; nanoparticles; nanoprecipitation; self-assembly
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MDPI and ACS Style

Xu, J.; Chen, Y.; Jiang, X.; Gui, Z.; Zhang, L. Development of Hydrophilic Drug Encapsulation and Controlled Release Using a Modified Nanoprecipitation Method. Processes 2019, 7, 331.

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