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Article

Green Synthesized Silver Nanoparticles of Myrtus communis L (AgMC) Extract Inhibits Cancer Hallmarks via Targeting Aldose Reductase (AR) and Associated Signaling Network

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Basic Medical Science Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 16278, Saudi Arabia
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Department of Pharmaceutics, College of Pharmacy, PO Box 2457, King Saud University, Riyadh 11451, Saudi Arabia
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Nano medicine Research unit (MNU), Pharmaceutical department, college of pharmacy, King Saud University. Riyadh 11451, Saudi Arabia
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Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia
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Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, King Saud University, Riyadh 11451, Saudi Arabia
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Author to whom correspondence should be addressed.
Processes 2019, 7(11), 860; https://doi.org/10.3390/pr7110860
Received: 17 October 2019 / Revised: 11 November 2019 / Accepted: 11 November 2019 / Published: 18 November 2019
(This article belongs to the Special Issue Production and Biomedical Applications of Bioactive Compounds)
In this current study, we demonstrated the green synthesis and characterization of silver nanoparticles using Myrtus communis L. plant extract (Ag-MC) and its evaluation of anticancer and antimicrobial activities. The green synthesis of (Ag-MC), was assessed by numerous characterization techniques such as ultraviolet-visible spectroscopy (UV-VIS), Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD) transmission electron microscopy (TEM) and energy dispersive x-ray spectroscopy (EDX). The anti-cancer activity of the green synthesized silver nanoparticles was evaluated by the median inhibitory dose (IC50) on human liver carcinoma cell lines (HepG2). These results suggested that SN-NPs can be used as effective anticancer cell lines, as well as antibacterial and antiseptic agents in the medical field. This study showed that overexpression of aldose reductase (AR) in the human liver carcinoma cell line, HepG2, was down regulated by administration of SN-MC. The down regulation of AR was associated with abrogation of Pl3k/Akt, ERK and NF-kB pathways and the inhibition of cancer hallmarks, however, the target molecule for Ag-MC was not practically established. Thus it is still unknown if the consequences were due to AR inhibition or direct Ag-MC interaction with AR. View Full-Text
Keywords: Myrtus communis L.; green synthesis; silver NPs; anti-cancer Myrtus communis L.; green synthesis; silver NPs; anti-cancer
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MDPI and ACS Style

Ali Abuderman, A.; Syed, R.; A. Alyousef, A.; S. Alqahtani, M.; Shamsul Ola, M.; Malik, A. Green Synthesized Silver Nanoparticles of Myrtus communis L (AgMC) Extract Inhibits Cancer Hallmarks via Targeting Aldose Reductase (AR) and Associated Signaling Network. Processes 2019, 7, 860. https://doi.org/10.3390/pr7110860

AMA Style

Ali Abuderman A, Syed R, A. Alyousef A, S. Alqahtani M, Shamsul Ola M, Malik A. Green Synthesized Silver Nanoparticles of Myrtus communis L (AgMC) Extract Inhibits Cancer Hallmarks via Targeting Aldose Reductase (AR) and Associated Signaling Network. Processes. 2019; 7(11):860. https://doi.org/10.3390/pr7110860

Chicago/Turabian Style

Ali Abuderman, Abdulwahab, Rabbani Syed, Abdullah A. Alyousef, Mohammed S. Alqahtani, Mohammad Shamsul Ola, and Abdul Malik. 2019. "Green Synthesized Silver Nanoparticles of Myrtus communis L (AgMC) Extract Inhibits Cancer Hallmarks via Targeting Aldose Reductase (AR) and Associated Signaling Network" Processes 7, no. 11: 860. https://doi.org/10.3390/pr7110860

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