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Antibacterial and Antifungal Activity of Novel Synthesized Neodymium-Substituted Cobalt Ferrite Nanoparticles for Biomedical Application

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Department of Epidemic Disease Research, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
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Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51431, Saudi Arabia
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National Center of Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11442, Saudi Arabia
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Department of Nano-Medicine Research, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
5
Department of Biology, College of Science/Basic and Applied Scientific Research Centre, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Processes 2019, 7(10), 714; https://doi.org/10.3390/pr7100714
Received: 20 August 2019 / Revised: 1 October 2019 / Accepted: 3 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Production and Biomedical Applications of Bioactive Compounds)
Neodymium (Nd)-substituted cobalt ferrite nanoparticles (NPs), i.e., CoNdxFe2−xO4 (0.0 ≤ x ≤ 0.2) NPs, were synthesized by the sonochemical method. The compositional characterization was done by scanning electron microscopy (SEM) equipped with energy-dispersive X-ray spectroscopy (EDX) and transmission electron microscopy (TEM). Antistaphylococcal activity was found to be enhanced, i.e., survival rate was 50%, 45%, 40%, and 30% with the increase in the ratio of Nd (0.0 ≤ x ≤ 0.2), whereas anticandidal activity was found efficient, i.e., 9%, 20%, 22%, and 40% survival rate at all the four ratios. The morphogenesis studies indicated that the synthesized metal–ligand, improves the antimicrobial capacity by binding them strongly to the microbial walls. To the best of our knowledge, this is the first report which demonstrates the series of CoNdxFe2−xO4 (0.0 ≤ x ≤ 0.2) NPs being active towards Staphylococcus aureus and Candida albicans and encourages its potential candidature for pharmaceutical and biomedical purposes. View Full-Text
Keywords: neodymium; magnetic nanomaterials; spinel ferrites; antibacterial activity; yeast; bioactivity neodymium; magnetic nanomaterials; spinel ferrites; antibacterial activity; yeast; bioactivity
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Rehman, S.; Ansari, M.A.; Alzohairy, M.A.; Alomary, M.N.; Jermy, B.R.; Shahzad, R.; Tashkandi, N.; Alsalem, Z.H. Antibacterial and Antifungal Activity of Novel Synthesized Neodymium-Substituted Cobalt Ferrite Nanoparticles for Biomedical Application. Processes 2019, 7, 714.

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