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Article

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

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Tra Vinh University, No. 126, Nguyen Thien Thanh, Ward 5, Tra Vinh city 940000, Vietnam
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Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam
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Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam
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Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam
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NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
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Center of Excellence for Functional Polymers and NanoEngineering, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
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Department of Orthopedic, 7A Military Hospital, 466 Nguyen Trai Street, Ward 8, District 5, 72706, Ho Chi Minh City 700000, Vietnam
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Nghe An Oncology Hospital, Vinh City 460000, Vietnam
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Authors to whom correspondence should be addressed.
Processes 2019, 7(11), 805; https://doi.org/10.3390/pr7110805
Received: 23 June 2019 / Revised: 4 August 2019 / Accepted: 29 August 2019 / Published: 4 November 2019
(This article belongs to the Special Issue Synthesis and Characterization of Biomedical Materials)
As a promising candidate for expanding the capacity of drug loading in silica nanoplatforms, hollow mesoporous silica nanoparticles (HMSNs) are gaining increasing attention. In this study, porous nanosilica (PNS) and HMSNs were prepared by the sol-gel method and template assisted method, then further used for Rhodamine (RhB) loading. To characterize the as-synthesized nanocarriers, a number of techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption-desorption isotherms, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR) were employed. The size of HMSN nanoparticles in aqueous solution averaged 134.0 ± 0.3 nm, which could be adjusted by minor changes during synthesis, whereas that of PNS nanoparticles was 63.4 ± 0.6 nm. In addition, the encapsulation of RhB into HMSN nanoparticles to form RhB-loaded nanocarriers (RhB/HMSN) was successful, achieving high loading efficiency (51.67% ± 0.11%). This was significantly higher than that of RhB-loaded PNS (RhB/PNS) (12.24% ± 0.24%). Similarly, RhB/HMSN also possessed a higher RhB loading content (10.44% ± 0.02%) compared to RhB/PNS (2.90% ± 0.05%). From those results, it is suggested that prepared HMSN nanocarriers may act as high-capacity carriers in drug delivery applications. View Full-Text
Keywords: hollow mesoporous silica; porous silica; high drug loading capacity; nanoparticles; drug delivery system hollow mesoporous silica; porous silica; high drug loading capacity; nanoparticles; drug delivery system
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MDPI and ACS Style

Nguyen-Thi, N.-T.; Pham Tran, L.P.; Le, N.T.T.; Cao, M.-T.; Tran, T.-N.; Nguyen, N.T.; Nguyen, C.H.; Nguyen, D.-H.; Than, V.T.; Le, Q.T.; Trung, N.Q. The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity. Processes 2019, 7, 805. https://doi.org/10.3390/pr7110805

AMA Style

Nguyen-Thi N-T, Pham Tran LP, Le NTT, Cao M-T, Tran T-N, Nguyen NT, Nguyen CH, Nguyen D-H, Than VT, Le QT, Trung NQ. The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity. Processes. 2019; 7(11):805. https://doi.org/10.3390/pr7110805

Chicago/Turabian Style

Nguyen-Thi, Ngoc-Tram, Linh P. Pham Tran, Ngoc T.T. Le, Minh-Tri Cao, The-Nam Tran, Ngoc T. Nguyen, Cong H. Nguyen, Dai-Hai Nguyen, Van T. Than, Quang T. Le, and Nguyen Q. Trung. 2019. "The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity" Processes 7, no. 11: 805. https://doi.org/10.3390/pr7110805

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