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Article

Preventive and Regenerative Effect of Glutamine and Probiotics on Gastric Mucosa in an Experimental Model of Alcohol-Induced Injury in Male Holtzman Rats

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Faculty of Health Sciences, School of Human Nutrition, Norbert Wiener Private University, Lima 15108, Peru
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South American Center for Education and Research in Public Health, Universidad Norbert Wiener, Lima 15108, Peru
3
Automated Biotherium of the Office of the Vice Chancellor for Research, Andean University of Cusco, Cusco 08006, Peru
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Specialized Group of Nutrition in Peru (GENUP), Lima 07006, Peru
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Faculty of Sciences and Philosophy “Alberto Cazorla Talleri”, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
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San Fernando Faculty of Medicine, School of Nutrition, Universidad Nacional Mayor de San Marcos, Lima 15081, Peru
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Research Center, Universidad Norbert Wiener, Lima 15108, Peru
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Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Lima 15067, Peru
*
Author to whom correspondence should be addressed.
Academic Editor: Carla Silva
Processes 2022, 10(3), 504; https://doi.org/10.3390/pr10030504
Received: 1 January 2022 / Revised: 11 February 2022 / Accepted: 23 February 2022 / Published: 2 March 2022
Background: The purpose of this study was to measure the preventive and regenerative effect of glutamine and probiotics induced by alcohol injury in Holtzman rats. Methods: Analytical, experimental and prospective study. The population consisted of 56 male rats between 300 and 350 g, distributed in three experimental phases: Pre-pilot phase PPP (6 rats), Pilot phase PP (10 rats), and Experimental phase EP (40 rats). In the pilot phase, 10 rats were subjected to damage with 8.5% ethanol, which was given intragastrically. The dosage was calculated for 10 rats in two groups: the first with 7.5 mL/kg in 5 rats and the second with 8.5 mL/kg in 5 rats. The experimental phase was performed in 40 rats divided into 6 groups, the negative control group (healthy), positive control group (injured), preventive experimental group (glutamine and glutamine with probiotic) and regenerative experimental group (glutamine and glutamine with probiotic). At the end of each phase, the rats were sacrificed with sodium pentobarbital (Halathal) and a portion of their stomachs was stored in formol. Results: The evaluation of stomach tissue samples (desquamation, erythema, hyperemia) showed that in the preventive phase, glutamine shows effectiveness in comparison to glutamine with probiotic. In the regenerative phase, glutamine and glutamine with probiotic did not show significant differences. Conclusions: Glutamine and probiotics can potentially serve as a therapy for the treatment for gastritis. View Full-Text
Keywords: gastritis; glutamine; probiotics; gastric mucosa gastritis; glutamine; probiotics; gastric mucosa
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Figure 1

  • Externally hosted supplementary file 1
    Doi: https://doi.org/10.6084/m9.figshare.14751561
    Description: : Database: The data includes Experimental and prospective study, is the result of working with 56 male rats between 300 and 350 g, three phases were worked: the first the pre-pilot phase (6 rats), the second the pilot phase (10 rats) and the third experimental phase (40 rats).
MDPI and ACS Style

Lozada-Urbano, M.; Pitot, C.; Recoba-Obregón, P.; Paredes-Inofuente, D.; Cáceres, C.; Rivera-Lozada, O.; Inga-Berrospi, F.; Bonilla-Asalde, C. Preventive and Regenerative Effect of Glutamine and Probiotics on Gastric Mucosa in an Experimental Model of Alcohol-Induced Injury in Male Holtzman Rats. Processes 2022, 10, 504. https://doi.org/10.3390/pr10030504

AMA Style

Lozada-Urbano M, Pitot C, Recoba-Obregón P, Paredes-Inofuente D, Cáceres C, Rivera-Lozada O, Inga-Berrospi F, Bonilla-Asalde C. Preventive and Regenerative Effect of Glutamine and Probiotics on Gastric Mucosa in an Experimental Model of Alcohol-Induced Injury in Male Holtzman Rats. Processes. 2022; 10(3):504. https://doi.org/10.3390/pr10030504

Chicago/Turabian Style

Lozada-Urbano, Michelle, Christian Pitot, Paulo Recoba-Obregón, Diego Paredes-Inofuente, Cristina Cáceres, Oriana Rivera-Lozada, Fiorella Inga-Berrospi, and Cesar Bonilla-Asalde. 2022. "Preventive and Regenerative Effect of Glutamine and Probiotics on Gastric Mucosa in an Experimental Model of Alcohol-Induced Injury in Male Holtzman Rats" Processes 10, no. 3: 504. https://doi.org/10.3390/pr10030504

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