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Review

Hypersensitivity to Intravenous Iron Preparations

by
Silvia Caimmi
1,
Giuseppe Crisafulli
2,
Fabrizio Franceschini
3,
Lucia Liotti
3,
Annamaria Bianchi
4,
Paolo Bottau
5,
Francesca Mori
6,
Paolo Triggiano
1,
Claudia Paglialunga
7,
Francesca Saretta
8,
Arianna Giannetti
9,
Giampaolo Ricci
10 and
Carlo Caffarelli
11,*
1
UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
2
UOC Pediatria, Università di Messina, 98124 Messina, Italy
3
UOC Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, 60020 Ancona, Italy
4
UOC Pediatria, Azienda Ospedaliera San Camillo Forlanini, 00152 Roma, Italy
5
Dipartimento di Pediatria e Neonatologia, Ospedale di Imola, 40026 Imola, Italy
6
Allergy Unit, Meyer Children’s Hospital, 50139 Florence, Italy
7
UOC di Pediatria, Azienda Ospedaliera-Universitaria “Consorziale-Policlinico”, Ospedale Pediatrico Giovanni XXIII, 70123 Bari, Italy
8
SC Pediatria, Ospedale Latisana-Palmanova, Dipartimento Materno-Infantile Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy
9
Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
10
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy
11
Clinica Pediatrica, Azienda Ospedaliero-Universitaria, Dipartimento Medicina e Chirurgia, Università di Parma, 43126 Parma, Italy
 
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Author to whom correspondence should be addressed.
Children 2022, 9(10), 1473; https://doi.org/10.3390/children9101473
Submission received: 9 August 2022 / Revised: 10 September 2022 / Accepted: 15 September 2022 / Published: 27 September 2022
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Abstract

Intravenous iron is widely used for the treatment of iron deficiency anemia when adherence to oral iron replacement is poor. Acute hypersensitivity reactions during iron infusions are very rare but can be life threatening. Major risk factors for hypersensitivity reactions include a previous reaction to an iron infusion, a fast iron infusion rate, multiple drug allergies, atopic diseases, high serum tryptase levels, asthma, and urticaria. The management of iron infusions requires meticulous observation, and, in the event of an adverse reaction, prompt recognition and severity-related interventions by well-trained medical and nursing staff. Avoidance of IV iron products in patients with iron hypersensitivity reactions may not be considered as a standard practice.
Keywords: iron; iron hypersensitivity; desensitization; drug allergy; hypersensitivity reaction; drug provocation test iron; iron hypersensitivity; desensitization; drug allergy; hypersensitivity reaction; drug provocation test

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MDPI and ACS Style

Caimmi, S.; Crisafulli, G.; Franceschini, F.; Liotti, L.; Bianchi, A.; Bottau, P.; Mori, F.; Triggiano, P.; Paglialunga, C.; Saretta, F.; et al. Hypersensitivity to Intravenous Iron Preparations. Children 2022, 9, 1473. https://doi.org/10.3390/children9101473

AMA Style

Caimmi S, Crisafulli G, Franceschini F, Liotti L, Bianchi A, Bottau P, Mori F, Triggiano P, Paglialunga C, Saretta F, et al. Hypersensitivity to Intravenous Iron Preparations. Children. 2022; 9(10):1473. https://doi.org/10.3390/children9101473

Chicago/Turabian Style

Caimmi, Silvia, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Annamaria Bianchi, Paolo Bottau, Francesca Mori, Paolo Triggiano, Claudia Paglialunga, Francesca Saretta, and et al. 2022. "Hypersensitivity to Intravenous Iron Preparations" Children 9, no. 10: 1473. https://doi.org/10.3390/children9101473

APA Style

Caimmi, S., Crisafulli, G., Franceschini, F., Liotti, L., Bianchi, A., Bottau, P., Mori, F., Triggiano, P., Paglialunga, C., Saretta, F., Giannetti, A., Ricci, G., & Caffarelli, C. (2022). Hypersensitivity to Intravenous Iron Preparations. Children, 9(10), 1473. https://doi.org/10.3390/children9101473

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