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Epinephrine in Neonatal Resuscitation

UC Davis School of Medicine, Sacramento, CA 95817, USA
SUNY Buffalo, Buffalo, NY 14222, USA
Author to whom correspondence should be addressed.
Children 2019, 6(4), 51;
Received: 1 March 2019 / Revised: 28 March 2019 / Accepted: 29 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue Emerging Concepts in Neonatal Resuscitation)
PDF [2487 KB, uploaded 19 April 2019]


Epinephrine is the only medication recommended by the International Liaison Committee on Resuscitation for use in newborn resuscitation. Strong evidence from large clinical trials is lacking owing to the infrequent use of epinephrine during neonatal resuscitation. Current recommendations are weak as they are extrapolated from animal models or pediatric and adult studies that do not adequately depict the transitioning circulation and fluid-filled lungs of the newborn in the delivery room. Many gaps in knowledge including the optimal dosing, best route and timing of epinephrine administration warrant further studies. Experiments on a well-established ovine model of perinatal asphyxial cardiac arrest closely mimicking the newborn infant provide important information that can guide future clinical trials. View Full-Text
Keywords: resuscitation; epinephrine; newborn; intravenous; intraosseous; intramuscular resuscitation; epinephrine; newborn; intravenous; intraosseous; intramuscular

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Vali, P.; Sankaran, D.; Rawat, M.; Berkelhamer, S.; Lakshminrusimha, S. Epinephrine in Neonatal Resuscitation. Children 2019, 6, 51.

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