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Children 2018, 5(11), 143; https://doi.org/10.3390/children5110143

Pediatric Solid Tumors in Resource-Constrained Settings: A Review of Available Evidence on Management, Outcomes, and Barriers to Care

1
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
2
Department of Pediatrics, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
3
Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
4
Department of Paediatric Surgery, AIC-Kijabe Hospital, Kijabe 00220, Kenya
*
Author to whom correspondence should be addressed.
Received: 30 September 2018 / Revised: 17 October 2018 / Accepted: 18 October 2018 / Published: 23 October 2018
(This article belongs to the Special Issue Pediatric Surgical Oncology)
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PDF [474 KB, uploaded 23 October 2018]

Abstract

International disparities in outcomes from pediatric solid tumors remain striking. Herein, we review the current literature regarding management, outcomes, and barriers to care for pediatric solid tumors in low- and middle-income countries (LMICs). In sub-Saharan Africa, Wilms Tumor represents the most commonly encountered solid tumor of childhood and has been the primary target of recent efforts to improve outcomes in low-resource settings. Aggressive and treatment-resistant tumor biology may play a role in poor outcomes within certain populations, but socioeconomic barriers remain the principal drivers of preventable mortality. Management protocols that include measures to address socioeconomic barriers have demonstrated early success in reducing abandonment of therapy. Further work is required to improve infrastructure and general pediatric care to address disparities. View Full-Text
Keywords: Wilms Tumor; pediatric solid tumor; low and middle-income countries (LMICs); disparities; barriers to care Wilms Tumor; pediatric solid tumor; low and middle-income countries (LMICs); disparities; barriers to care
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Carter, N.H.; Avery, A.H.; Libes, J.; Lovvorn, H.N., III; Hansen, E.N. Pediatric Solid Tumors in Resource-Constrained Settings: A Review of Available Evidence on Management, Outcomes, and Barriers to Care. Children 2018, 5, 143.

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