Next Article in Journal
Adolescents’ Knowledge of Breastfeeding and Their Intention to Breastfeed in the Future
Next Article in Special Issue
The Association between Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk in Children
Previous Article in Journal / Special Issue
Pediatric Non-Alcoholic Fatty Liver Disease
Article Menu

Export Article

Open AccessReview
Children 2017, 4(6), 49;

The Association between Pediatric NAFLD and Common Genetic Variants

Department of Pediatrics, Yale University, 06520, New Haven, CT, USA
Dipartimento della Donna, del Bambino, di Vhirurgia Generale e Specialistica, Universita’ della Campania Luigi Vanvitelli, 80138, Napoli, Italy
Dipartimento di Medicina V. Tiberio, Universita’ del Molise, 86100, Campobasso, Italy
Author to whom correspondence should be addressed.
Received: 31 March 2017 / Revised: 14 June 2017 / Accepted: 15 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Pediatric Nonalcoholic Fatty Liver Disease)
Full-Text   |   PDF [1193 KB, uploaded 18 June 2017]


Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Several studies have shown that genetic predisposition probably plays an important role in its pathogenesis. In fact, in the last few years a large number of genetic studies have provided compelling evidence that some gene variants, especially those in genes encoding proteins regulating lipid metabolism, are associated with intra-hepatic fat accumulation. Here we provide a comprehensive review of the gene variants that have affected the natural history of the disease. View Full-Text
Keywords: NAFLD; children; genetics NAFLD; children; genetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Umano, G.R.; Martino, M.; Santoro, N. The Association between Pediatric NAFLD and Common Genetic Variants. Children 2017, 4, 49.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Children EISSN 2227-9067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top