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The Role of Lipid and Lipoprotein Metabolism in Non‐Alcoholic Fatty Liver Disease
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Pediatric Non-Alcoholic Fatty Liver Disease

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA 22042, USA
Center For Liver Disease, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA 22042, USA
Author to whom correspondence should be addressed.
Academic Editor: Lucia Pacifico
Children 2017, 4(6), 48;
Received: 1 May 2017 / Revised: 5 June 2017 / Accepted: 7 June 2017 / Published: 9 June 2017
(This article belongs to the Special Issue Pediatric Nonalcoholic Fatty Liver Disease)
PDF [214 KB, uploaded 12 June 2017]


Abstract: With the increase in the prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) has become among the leading causes of chronic liver disease in the pediatric age group. Once believed to be a “two-hit process”, it is now clear that the actual pathophysiology of NAFLD is complex and involves multiple pathways. Moreover, NAFLD is not always benign, and patients with non-alcoholic steatohepatitis (NASH) are at increased risk of developing advanced stages of liver disease. It has also been shown that NAFLD is not only a liver disease, but is also associated with multiple extrahepatic manifestations, including cardiovascular diseases, type 2 diabetes, and low bone mineral density. Although the data is scarce in the pediatric population, some studies have suggested that long-term mortality and the requirement of liver transplantation will continue to increase in patients with NAFLD. More studies are needed to better understand the natural history of NAFLD, especially in the pediatric age group. View Full-Text
Keywords: NAFLD; children; genetics; epidemiology; natural history; obesity; metabolic syndrome NAFLD; children; genetics; epidemiology; natural history; obesity; metabolic syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bush, H.; Golabi, P.; Younossi, Z.M. Pediatric Non-Alcoholic Fatty Liver Disease. Children 2017, 4, 48.

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