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Article

Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study

by
Maura-Adelina Hincu
1,
Gabriela-Ildiko Zonda
1,*,
Petronela Vicoveanu
2,
Valeriu Harabor
3,
Anamaria Harabor
3,
Alexandru Carauleanu
1,
Alina-Sînziana Melinte-Popescu
4,
Marian Melinte-Popescu
5,
Elena Mihalceanu
1,
Mariana Stuparu-Cretu
3,
Ingrid-Andrada Vasilache
3,
Dragos Nemescu
1 and
Luminita Paduraru
1
1
Division of Neonatology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2
Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
3
Clinical and Surgical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800216 Galati, Romania
4
Department of Mother and Newborn Care, Faculty of Medicine and Biological Sciences, ‘Ștefan cel Mare’ University, 720229 Suceava, Romania
5
Department of Internal Medicine, Faculty of Medicine and Biological Sciences, ‘Ștefan cel Mare’ University, 720229 Suceava, Romania
*
Author to whom correspondence should be addressed.
Children 2024, 11(1), 124; https://doi.org/10.3390/children11010124
Submission received: 1 December 2023 / Revised: 13 January 2024 / Accepted: 16 January 2024 / Published: 18 January 2024
(This article belongs to the Special Issue Intensive Care for Critically Ill Neonates: Clinical Diagnosis and Treatment)
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Abstract

(1) Background: Neonatal early-onset sepsis (EOS) is associated with important mortality and morbidity. The aims of this study were to evaluate the association between serum and hematological biomarkers with early onset neonatal sepsis in a cohort of patients with prolonged rupture of membranes (PROM) and to calculate their diagnostic accuracy. (2) Methods: A retrospective cohort study was conducted on 1355 newborns with PROM admitted between January 2017 and March 2020, who were divided into two groups: group A, with PROM ≥ 18 h, and group B, with ROM < 18 h. Both groups were further split into subgroups: proven sepsis, presumed sepsis, and no sepsis. Descriptive statistics, analysis of variance (ANOVA) and a Random Effects Generalized Least Squares (GLS) regression were used to evaluate the data. (3) Results: The statistically significant predictors of neonatal sepsis were the high white blood cell count from the first (p = 0.005) and third day (p = 0.028), and high C-reactive protein (CRP) values from the first day (p = 0.004). Procalcitonin (area under the curve—AUC = 0.78) and CRP (AUC = 0.76) measured on the first day had the best predictive performance for early-onset neonatal sepsis. (4) Conclusions: Our results outline the feasibility of using procalcitonin and CRP measured on the first day taken individually in order to increase the detection rate of early-onset neonatal sepsis, in the absence of positive blood culture.
Keywords: early-onset sepsis; biomarker; c-reactive protein; procalcitonin; white blood count; antibiotics early-onset sepsis; biomarker; c-reactive protein; procalcitonin; white blood count; antibiotics

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MDPI and ACS Style

Hincu, M.-A.; Zonda, G.-I.; Vicoveanu, P.; Harabor, V.; Harabor, A.; Carauleanu, A.; Melinte-Popescu, A.-S.; Melinte-Popescu, M.; Mihalceanu, E.; Stuparu-Cretu, M.; et al. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children 2024, 11, 124. https://doi.org/10.3390/children11010124

AMA Style

Hincu M-A, Zonda G-I, Vicoveanu P, Harabor V, Harabor A, Carauleanu A, Melinte-Popescu A-S, Melinte-Popescu M, Mihalceanu E, Stuparu-Cretu M, et al. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children. 2024; 11(1):124. https://doi.org/10.3390/children11010124

Chicago/Turabian Style

Hincu, Maura-Adelina, Gabriela-Ildiko Zonda, Petronela Vicoveanu, Valeriu Harabor, Anamaria Harabor, Alexandru Carauleanu, Alina-Sînziana Melinte-Popescu, Marian Melinte-Popescu, Elena Mihalceanu, Mariana Stuparu-Cretu, and et al. 2024. "Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study" Children 11, no. 1: 124. https://doi.org/10.3390/children11010124

APA Style

Hincu, M.-A., Zonda, G.-I., Vicoveanu, P., Harabor, V., Harabor, A., Carauleanu, A., Melinte-Popescu, A.-S., Melinte-Popescu, M., Mihalceanu, E., Stuparu-Cretu, M., Vasilache, I.-A., Nemescu, D., & Paduraru, L. (2024). Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children, 11(1), 124. https://doi.org/10.3390/children11010124

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