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Volume 10
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10.3390/children10121903
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Background:
Systematic Review

Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis

by
Mohamad F. Almutairi
1,
Silvia Gulden
2,
Tamara M. Hundscheid
1,
František Bartoš
3,
Giacomo Cavallaro
4 and
Eduardo Villamor
1,*
1
Division of Neonatology, Department of Pediatrics, MosaKids Children’s Hospital, Maastricht University Medical Center (MUMC+), School for Oncology and Reproduction (GROW), Maastricht University, 6202 AZ Maastricht, The Netherlands
2
Neonatal Intensive Care Unit, Sant’Anna Hospital, 22020 Como, Italy
3
Department of Psychology, University of Amsterdam, 1001 NK Amsterdam, The Netherlands
4
Neonatal Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Children 2023, 10(12), 1903; https://doi.org/10.3390/children10121903
Submission received: 7 November 2023 / Revised: 4 December 2023 / Accepted: 7 December 2023 / Published: 8 December 2023
(This article belongs to the Special Issue Intensive Care for Critically Ill Neonates: Clinical Diagnosis and Treatment)
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Abstract

Background: We aimed to conduct a systematic review and Bayesian model-averaged meta-analysis (BMA) on the association between platelet counts and severe retinopathy of prematurity (ROP). Methods: We searched for studies reporting on platelet counts (continuous variable) or thrombocytopenia (categorical variable) and severe ROP or aggressive posterior ROP (APROP). The timing of platelet counts was divided into Phase 1 (<2 weeks) and Phase 2 (around ROP treatment). BMA was used to calculate Bayes factors (BFs). The BF10 is the ratio of the probability of the data under the alternative hypothesis (H1) over the probability of the data under the null hypothesis (H0). Results: We included 21 studies. BMA showed an association between low platelet counts and severe ROP. The evidence was strong (BF10 = 13.5, 7 studies) for phase 1 and very strong (BF10 = 51.0, 9 studies) for phase 2. Thrombocytopenia (<100 × 109/L) in phase 2 was associated with severe ROP (BF10 = 28.2, 4 studies). Following adjustment for publication bias, only the association of severe ROP with thrombocytopenia remained with moderate evidence in favor of H1 (BF10 = 4.30). Conclusions: Thrombocytopenia is associated with severe ROP. However, the evidence for this association was tempered when results were adjusted for publication bias.
Keywords: thrombocytopenia; platelets; retinopathy of prematurity thrombocytopenia; platelets; retinopathy of prematurity

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MDPI and ACS Style

Almutairi, M.F.; Gulden, S.; Hundscheid, T.M.; Bartoš, F.; Cavallaro, G.; Villamor, E. Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis. Children 2023, 10, 1903. https://doi.org/10.3390/children10121903

AMA Style

Almutairi MF, Gulden S, Hundscheid TM, Bartoš F, Cavallaro G, Villamor E. Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis. Children. 2023; 10(12):1903. https://doi.org/10.3390/children10121903

Chicago/Turabian Style

Almutairi, Mohamad F., Silvia Gulden, Tamara M. Hundscheid, František Bartoš, Giacomo Cavallaro, and Eduardo Villamor. 2023. "Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis" Children 10, no. 12: 1903. https://doi.org/10.3390/children10121903

APA Style

Almutairi, M. F., Gulden, S., Hundscheid, T. M., Bartoš, F., Cavallaro, G., & Villamor, E. (2023). Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis. Children, 10(12), 1903. https://doi.org/10.3390/children10121903

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